Asset Details
Do you wish to reserve the book?
The NUDIX hydrolase NUDT5 influences purine nucleotide metabolism and thiopurine pharmacology
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
The NUDIX hydrolase NUDT5 influences purine nucleotide metabolism and thiopurine pharmacology
Do you wish to request the book?
The NUDIX hydrolase NUDT5 influences purine nucleotide metabolism and thiopurine pharmacology
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
The NUDIX hydrolase NUDT5 influences purine nucleotide metabolism and thiopurine pharmacology
2025
Overview
Purine nucleotides are critical for nucleic acid synthesis, signaling, and cellular metabolism. Thiopurines (TPs), including 6-mercaptopurine and 6-thioguanine, are cornerstone agents for the treatment of acute lymphoblastic leukemia (ALL). TP efficacy and cytotoxicity depend on the metabolism and intracellular activation of TPs, a process influenced by pharmacogenes such as thiopurine-S methyltransferase (TPMT) and NUDIX (nucleoside diphosphates linked to moiety-X) hydrolase 15 (NUDT15). In this issue of the JCI, Maillard et al. identified NUDT5 as a determinant of TP pharmacology. They demonstrated that loss of NUDT5 conferred TP resistance by impairing drug activation and DNA damage responses. Metabolomics studies by Maillard and others revealed that NUDT5 may regulate the balance between the de novo purine synthesis and salvage pathways. Clinically, NUDT5 expression variants were associated with altered TP tolerance. These findings position NUDT5 as a key modulator of nucleotide metabolism and TP efficacy, with potential implications for pharmacogenomics-guided therapy optimization in ALL.
Publisher
American Society for Clinical Investigation
Subject
/ Acute lymphoblastic leukemia
/ Animals
/ Antimetabolites, Antineoplastic - pharmacology
/ Antimetabolites, Antineoplastic - therapeutic use
/ Cancer
/ CRISPR
/ Enzymes
/ Humans
/ Leukemia
/ Mercaptopurine - pharmacology
/ Mercaptopurine - therapeutic use
/ Methyltransferases - genetics
/ Methyltransferases - metabolism
/ Precursor Cell Lymphoblastic Leukemia-Lymphoma - drug therapy
/ Precursor Cell Lymphoblastic Leukemia-Lymphoma - enzymology
/ Precursor Cell Lymphoblastic Leukemia-Lymphoma - genetics
/ Purine Nucleotides - metabolism
/ Pyrophosphatases - metabolism
/ Pyrophosphatases - physiology
/ Thioguanine - therapeutic use
/ Toxicity
