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Functional Analysis of the LACERATA Gene of Arabidopsis Provides Evidence for Different Roles of Fatty Acid ω-Hydroxylation in Development
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Functional Analysis of the LACERATA Gene of Arabidopsis Provides Evidence for Different Roles of Fatty Acid ω-Hydroxylation in Development
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Journal Article
Functional Analysis of the LACERATA Gene of Arabidopsis Provides Evidence for Different Roles of Fatty Acid ω-Hydroxylation in Development
2001
Overview
We describe lacerata (lcr) mutants of Arabidopsis, which display various developmental abnormalities, including postgenital organ fusions, and report cloning of the LCR gene by using the maize transposon Enhancer/Suppressor-mutator (En/Spm). The pleiotropic mutant phenotype could be rescued by genetic complementation of lcr mutants with the wild-type LCR gene. The LCR gene encodes a cytochrome P450 monooxygenase, CYP86A8, which catalyzes ω-hydroxylation of fatty acids ranging from C12 to C18:1, as demonstrated by expression of the gene in yeast. Although palmitic and oleic acids were efficient substrates for LCR, 9,10-epoxystearate was not metabolized. Taken together with previous studies, our findings indicate that LCR-dependent ω-hydroxylation of fatty acids could be implicated in the biosynthesis of cutin in the epidermis and in preventing postgenital organ fusions. Strikingly, the same pathway seems to control trichome differentiation, the establishment of apical dominance, and senescence in plants.
Publisher
National Academy of Sciences,National Acad Sciences
Subject
/ Arabidopsis - growth & development
/ Cloning
/ Cytochrome P-450 Enzyme System
/ Cytochrome P-450 Enzyme System - genetics
/ Cytochrome P-450 Enzyme System - physiology
/ cytochrome P450 monooxygenase
/ DNA Transposable Elements - genetics
/ Genes
/ Genetic Complementation Test
/ genetics
/ LCR gene
/ Membrane Lipids - biosynthesis
/ Mixed Function Oxygenases - genetics
/ Mixed Function Oxygenases - physiology
/ mutants
/ Plant Epidermis - metabolism
/ Plants
/ Plants, Genetically Modified
/ Recombinant Fusion Proteins - metabolism
/ Saccharomyces cerevisiae - metabolism
