Journal Article

Visualizing “featureless” regions on mammograms classified as invasive ductal carcinomas by a deep learning algorithm: the promise of AI support in radiology

Takashima Tsutomu, Tsutsumi Shinichi, Miki Yukio, Noda Satoru, Morisaki Tamami, Kashiwagi Shinichiro, Yamamoto, Akira, Shimazaki Akitoshi, Onoda Naoyoshi, Honjo Takashi, Goto Takuya, Ueda Daiju

2021

Overview

PurposeTo demonstrate how artificial intelligence (AI) can expand radiologists’ capacity, we visualized the features of invasive ductal carcinomas (IDCs) that our algorithm, developed and validated for basic pathological classification on mammograms, had focused on.Materials and methodsIDC datasets were built using mammograms from patients diagnosed with IDCs from January 2006 to December 2017. The developing dataset was used to train and validate a VGG-16 deep learning (DL) network. The true positives (TPs) and accuracy of the algorithm were externally evaluated using the test dataset. A visualization technique was applied to the algorithm to determine which malignant findings on mammograms were revealed.ResultsThe datasets were split into a developing dataset (988 images) and a test dataset (131 images). The proposed algorithm diagnosed 62 TPs with an accuracy of 0.61–0.70. The visualization of features on the mammograms revealed that the tubule forming, solid, and scirrhous types of IDCs exhibited visible features on the surroundings, corners of the masses, and architectural distortions, respectively.ConclusionWe successfully showed that features isolated by a DL-based algorithm trained to classify IDCs were indeed those known to be associated with each pathology. Thus, using AI can expand the capacity of radiologists through the discovery of previously unknown findings.

• Publisher: Springer Nature B.V
• Subject: Algorithms / Artificial intelligence / Breast cancer / Carcinoma / Datasets / Deep learning / Machine learning / Medical diagnosis / Medical imaging / Radiology / Visualization