Asset Details
Do you wish to reserve the book?
Quinoline Functionalized Schiff Base Silver (I) Complexes: Interactions with Biomolecules and In Vitro Cytotoxicity, Antioxidant and Antimicrobial Activities
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Quinoline Functionalized Schiff Base Silver (I) Complexes: Interactions with Biomolecules and In Vitro Cytotoxicity, Antioxidant and Antimicrobial Activities
Do you wish to request the book?
Quinoline Functionalized Schiff Base Silver (I) Complexes: Interactions with Biomolecules and In Vitro Cytotoxicity, Antioxidant and Antimicrobial Activities
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Quinoline Functionalized Schiff Base Silver (I) Complexes: Interactions with Biomolecules and In Vitro Cytotoxicity, Antioxidant and Antimicrobial Activities
2021
Overview
A series of fifteen silver (I) quinoline complexes
-
have been synthesized and studied for their biological activities.
-
were synthesized from the reactions of quinolinyl Schiff base derivatives
-
(obtained by condensing 2-quinolinecarboxaldehyde with various aniline derivatives) with AgNO
, AgClO
and AgCF
SO
.
-
were characterized by various spectroscopic techniques and the structures of [Ag(
)
]NO
, [Ag(
)
]ClO
, [Ag(
)
]ClO
, [Ag(
)
]CF
SO
and [Ag(
)
]CF
SO
were unequivocally determined by single crystal X-ray diffraction analysis. In vitro antimicrobial tests against Gram-positive and Gram-negative bacteria revealed the influence of structure and anion on the complexes' moderate to excellent antibacterial activity. In vitro antioxidant activities of the complexes showed their good radical scavenging activity in ferric reducing antioxidant power (FRAP). Complexes with the fluorine substituent or the thiophene or benzothiazole moieties are more potent with IC
between 0.95 and 2.22 mg/mL than the standard used, ascorbic acid (2.68 mg/mL). The compounds showed a strong binding affinity with calf thymus-DNA via an intercalation mode and protein through a static quenching mechanism. Cytotoxicity activity was examined against three carcinoma cell lines (HELA, MDA-MB231, and SHSY5Y). [Ag(
)
]ClO
with a benzothiazole moiety and [Ag(
)
]ClO
with a methyl substituent had excellent cytotoxicity against HELA cells.
Publisher
MDPI,MDPI AG
Subject
/ Anti-Bacterial Agents - chemical synthesis
/ Anti-Bacterial Agents - chemistry
/ Anti-Bacterial Agents - pharmacology
/ Antineoplastic Agents - chemical synthesis
/ Antineoplastic Agents - chemistry
/ Antineoplastic Agents - pharmacology
/ Antioxidants - chemical synthesis
/ Cell Proliferation - drug effects
/ Coordination Complexes - chemical synthesis
/ Coordination Complexes - chemistry
/ Coordination Complexes - pharmacology
/ CT-DNA
/ Drug Screening Assays, Antitumor
/ Ferric Compounds - antagonists & inhibitors
/ Gram-Negative Bacteria - drug effects
/ Gram-Positive Bacteria - drug effects
/ Humans
