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Oligonucleotide-based targeted gene editing in C. elegans via the CRISPR/Cas9 system
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Oligonucleotide-based targeted gene editing in C. elegans via the CRISPR/Cas9 system
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Journal Article
Oligonucleotide-based targeted gene editing in C. elegans via the CRISPR/Cas9 system
2014
Overview
Dear Editor,
Technologies to achieve specific and precise genome editing, such as knock-in and knock-out, are critical for deciphering the functions of a gene and for under- standing fundamental biological processes. Compared with the zinc finger nucleases （ZFN） and transcription activator-like effector nucleases （TALEN）, which have been used for genome editing [1], the Clustered Regu- larly Interspaced Short Palindromic Repeats （CRISPR）/ CRISPR-associated （Cas） system has emerged as a new powerful tool for genome modifications. It has recently been adopted for genome editing in human cell lines [2- 4], mouse [5], zebrafisb [6], C. elegans [7-12], and plants [13].
Publisher
Nature Publishing Group UK,Nature Publishing Group
Subject
/ Animals
/ Animals, Genetically Modified - genetics
/ Biomedical and Life Sciences
/ Caenorhabditis elegans - genetics
/ Caenorhabditis elegans Proteins - chemistry
/ Caenorhabditis elegans Proteins - genetics
/ Caenorhabditis elegans Proteins - metabolism
/ CRISPR-Associated Proteins - genetics
/ Nerve Tissue Proteins - genetics
/ Nerve Tissue Proteins - metabolism
/ 基因敲除
/ 基因组
/ 寡核苷酸
/ 生物过程
/ 系统
/ 线虫
/ 编辑
/ 靶基因
