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TLE4 Is a Critical Mediator of Osteoblast and Runx2-Dependent Bone Development
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Journal Article
TLE4 Is a Critical Mediator of Osteoblast and Runx2-Dependent Bone Development
2021
Overview
Healthy bone homeostasis hinges upon a delicate balance and regulation of multiple processes that contribute to bone development and metabolism. While examining hematopoietic regulation by
Tle4
, we have uncovered a previously unappreciated role of
Tle4
on bone calcification using a novel
Tle4
null mouse model. Given the significance of osteoblasts in both hematopoiesis and bone development, this study investigated how loss of
Tle4
affects osteoblast function. We used dynamic bone formation parameters and microCT to characterize the adverse effects of
Tle4
loss on bone development. We further demonstrated loss of
Tle4
impacts expression of several key osteoblastogenic genes, including
Runx2
,
Oc
, and
Ap
, pointing toward a potential novel mechanism for
Tle4
-dependent regulation of mammalian bone development in collaboration with the RUNX family members.
Publisher
Frontiers Media S.A
Subject
