Asset Details
Do you wish to reserve the book?
Intermittent or daily administration of 1-alpha calcidol for nephrectomised infants on peritoneal dialysis?
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Intermittent or daily administration of 1-alpha calcidol for nephrectomised infants on peritoneal dialysis?
Do you wish to request the book?
Intermittent or daily administration of 1-alpha calcidol for nephrectomised infants on peritoneal dialysis?
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Intermittent or daily administration of 1-alpha calcidol for nephrectomised infants on peritoneal dialysis?
2007
Overview
Secondary hyperparathyroidism and renal osteodystrophy are major problems in patients with end-stage renal failure and may result in poor growth in children on dialysis. Whether vitamin D sterols should be given intermittently or daily remains a controversial issue. We studied 16 bilaterally nephrectomised infants with congenital nephrosis of the Finnish type (median age 0.54 years), all on peritoneal dialysis. Nine of them were receiving intermittent 1-alpha calcidol therapy and seven daily 1-alpha calcidol therapy. The target serum parathyroid hormone (PTH) level was 2-3 times the upper limit of normal (ULN). There were no statistically significant differences in PTH values between the groups (1.7-times vs 0.5-times the ULN at 3 months and 3.1-times vs 3.4-times the ULN at 6 months, respectively). The required weekly doses of 1-alpha calcidol were low, and there were no significant differences between the intermittent and daily groups (0.06 microg/kg vs 0.04 microg/kg at 3 months and 0.09 microg/kg vs 0.05 microg/kg at 6 months, respectively). The infants on intermittent 1-alpha calcidol showed significant catch-up growth during dialysis after nephrectomy relative to the infants on daily 1-alpha calcidol (-1.6 SD to -0.7 SD vs -1.4 SD to -1.0 SD, respectively; P < 0.05). Our results indicate that either intermittent or daily vitamin D analogue therapy, if started early, will prevent secondary hyperparathyroidism equally well in children on peritoneal dialysis (PD), but intermittent therapy might be more favourable for growth.
Publisher
Springer,Springer Nature B.V
Subject
Bone Density Conservation Agents - administration & dosage
/ Chronic Kidney Disease-Mineral and Bone Disorder - drug therapy
/ Chronic Kidney Disease-Mineral and Bone Disorder - etiology
/ Complications and side effects
/ Continuous ambulatory peritoneal dialysis
/ Female
/ Humans
/ Hydroxycholecalciferols - administration & dosage
/ Infant
/ Kidney Failure, Chronic - complications
/ Kidney Failure, Chronic - surgery
/ Kidney Failure, Chronic - therapy
/ Male
/ Patients
/ Proteins
/ Sterols
