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Increased levels of sperm protein 17 mRNA and circulating antibodies in periampullary carcinoma patients
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Increased levels of sperm protein 17 mRNA and circulating antibodies in periampullary carcinoma patients
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Journal Article
Increased levels of sperm protein 17 mRNA and circulating antibodies in periampullary carcinoma patients
2015
Overview
Background
Present-day diagnostic modalities for detecting periampullary carcinoma are suboptimal, and currently used proven markers lack specificity and sensitivity.
Methods
In order to assess the diagnostic potential of sperm protein 17, a cancer testis antigen, quantitative real-time PCR was performed to evaluate the expression of sperm protein 17 in tissue and sera specimens collected from periampullary carcinoma patients and normal subjects. Additionally, circulating levels of anti-sperm protein 17 antibodies were determined in sera of periampullary carcinoma patients and normal subjects using ELISA.
Results
Aberrant expression of sperm protein 17 was found in 14/15 (93 %) periampullary cancer tissues when compared with distant matched nonmalignant tissues (
P
= 0.006, Mann–Whitney
U
test). None of the distant matched nonmalignant tissues showed increased expression of sperm protein 17 mRNA. Area under the curve, sensitivity, and specificity were 0.791, 87, and 73 %, respectively. Increased levels of sperm protein 17 mRNA were demonstrated in sera of periampullary carcinoma patients (
P
= 0.020, Student’s
t
test). Circulating levels of anti-sperm protein 17 antibody were found to be significantly elevated in 27/30 (90 %) periampullary carcinoma patients (
P
< 0.001, Student’s
t
test). Area under the curve, sensitivity, and specificity were 0.954, 86.7, and 96.3 %, respectively. Only two of the normal subjects (7 %) showed elevated levels of anti-sperm protein 17 antibody.
Conclusion
For the first time, our findings suggest that high levels of sperm protein 17 mRNA as well as increased circulating anti-sperm protein 17 antibodies can be used to distinguish periampullary cancer patients from healthy individuals, highlighting the diagnostic potential of sperm protein 17.
Publisher
Springer Japan,Springer Nature B.V
Subject
/ Antigens, Surface - biosynthesis
/ Biomarkers, Tumor - biosynthesis
/ Cancer
/ Carrier Proteins - biosynthesis
/ Common Bile Duct - chemistry
/ Common Bile Duct - immunology
/ Common Bile Duct Neoplasms - blood
/ Common Bile Duct Neoplasms - immunology
/ Common Bile Duct Neoplasms - metabolism
/ Humans
/ Male
/ Medicine
/ Oncology
/ Proteins
