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When Functional Assessment Meets Intravascular Imaging in Patients with Coronary Artery Disease

by Mplani, Virginia , Tsigkas, Grigorios , Davlouros, Periklis , Papafaklis, Michail I. , Apostolos, Anastasios , Spyropoulou, Panagiota , Rouzi, Stella , Nastouli, Kassiani-Maria , Tsimara, Effrosyni , Karanasos, Antonios , Bozika, Maria

in Adenosine / Angina pectoris / Cardiology / Cardiovascular disease / Care and treatment / Clinical outcomes / Complications and side effects / coronary artery disease / Coronary heart disease / Coronary vessels / Diagnostic imaging / Diseases / Evidence-based medicine / fractional flow reserve / Greece / Heart attacks / intravascular imaging / intravascular ultrasound / Intubation / Ischemia / Medical imaging / optical coherence tomography / Patients / Percutaneous Coronary Intervention / Physiology / Review / Stent (Surgery) / Tomography / Transluminal angioplasty / Ultrasonic imaging / Vein & artery diseases

2025

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When Functional Assessment Meets Intravascular Imaging in Patients with Coronary Artery Disease

2025

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When Functional Assessment Meets Intravascular Imaging in Patients with Coronary Artery Disease

2025

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Journal Article

When Functional Assessment Meets Intravascular Imaging in Patients with Coronary Artery Disease

Mplani, Virginia,

Tsigkas, Grigorios,

Davlouros, Periklis,

Papafaklis, Michail I.,

Apostolos, Anastasios,

Spyropoulou, Panagiota,

Rouzi, Stella,

Nastouli, Kassiani-Maria,

Tsimara, Effrosyni,

Karanasos, Antonios,

Bozika, Maria

2025

Overview

Percutaneous Coronary Intervention (PCI) has advanced significantly with the incorporation of imaging and physiology assessment techniques. Fractional Flow Reserve (FFR) and Non-Hyperemic Pressure indices (NHPIs) provide information regarding the functional significance of coronary lesions, while Intravascular Ultrasound (IVUS) and Optical Coherence Tomography (OCT) enhance anatomical characterization and guide stent implantation. This review explores the implementation of physiology- and imaging-guided strategies in clinical practice, comparing their efficacy and limitations. Novel technologies now allow for physiology estimation without hyperemic agents, and hybrid techniques, such as OCT-derived FFR, are increasingly integrated into clinical practice. These approaches offer the combined advantages of functional assessment and detailed anatomical imaging.

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Publisher

MDPI AG,MDPI

Subject

Adenosine

/ Angina pectoris

/ Cardiology

/ Cardiovascular disease

/ Care and treatment

/ Clinical outcomes

/ Complications and side effects