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The importance of understanding individual differences in Down syndrome version 1; peer review: 2 approved
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The importance of understanding individual differences in Down syndrome version 1; peer review: 2 approved
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Journal Article
The importance of understanding individual differences in Down syndrome version 1; peer review: 2 approved
2016
Overview
In this article, we first present a summary of the general assumptions about Down syndrome (DS) still to be found in the literature. We go on to show how new research has modified these assumptions, pointing to a wide range of individual differences at every level of description. We argue that, in the context of significant increases in DS life expectancy, a focus on individual differences in trisomy 21 at all levels-genetic, cellular, neural, cognitive, behavioral, and environmental-constitutes one of the best approaches for understanding genotype/phenotype relations in DS and for exploring risk and protective factors for Alzheimer's disease in this high-risk population.
Publisher
Faculty of 1000 Ltd,F1000Research,F1000 Research Ltd
