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Diagnosis and Management of the Antiphospholipid Syndrome
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Journal Article
Diagnosis and Management of the Antiphospholipid Syndrome
2018
Overview
To the Editor:
In their review article, Garcia and Erkan (May 24 issue)
1
describe current and future therapies in the prevention and treatment of thrombosis in patients with the antiphospholipid syndrome (APS). Direct oral anticoagulant therapy is mentioned as a possible therapeutic approach on the basis of the results of a randomized, controlled trial.
2
However, there is recent evidence that direct oral anticoagulants are less effective than warfarin in the prevention of recurrent thrombosis in patients with a high-risk profile (i.e., those who are triple-positive for lupus anticoagulant, anticardiolipin antibodies, and anti–β
2
-glycoprotein I antibodies). We retrospectively observed a higher rate . . .
Publisher
Massachusetts Medical Society
Subject
