Asset Details
Do you wish to reserve the book?
Antcin A, a steroid-like compound from Antrodia camphorata, exerts anti-inflammatory effect via mimicking glucocorticoids
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Antcin A, a steroid-like compound from Antrodia camphorata, exerts anti-inflammatory effect via mimicking glucocorticoids
Do you wish to request the book?
Antcin A, a steroid-like compound from Antrodia camphorata, exerts anti-inflammatory effect via mimicking glucocorticoids
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Antcin A, a steroid-like compound from Antrodia camphorata, exerts anti-inflammatory effect via mimicking glucocorticoids
2011
Overview
Aim： To determine the active ingredient of Niuchangchih （Antrodia camphorata） responsible for its anti-inflammatory effects and the relevant molecular mechanisms. Methods： Five major antcins （A, B, C, H, and K） were isolated from fruiting bodies of Niuchangchih. Structural similarity between the antcins and 2 glucocorticoids （cortisone and dexamethasone） was compared. After incubation with each compound, the cytosolic glucocorticoid receptor （GR） was examined for its migration into the nucleus. Molecular docking was performed to model the tertiary structure of GR associated with antcins. Results： Incubation with cortisone, dexamethasone or antcin A （but not antcins B, C, H, and K） led to the migration of glucocorticoid receptor into the nucleus. The minimal concentration of antcin A, cortisone and dexamethasone to induce nuclear migration of glu- cocorticoid receptor was 10, 1, and 0.1 mol/L, respectively. The results are in agreement with the simulated binding affinity scores of these three ligands docking to the glucocorticoid receptor. Molecular modeling indicates that C-7 of antcin A or glucocorticoids is exposed to a hydrophobic region in the binding cavity of the glucocorticoid receptor, and the attachment of a hydrophilic group to C-7 of the other four antcins presumably results in their being expelled when docking to the cavity. Conclusion： The anti-inflammatory effect of Niuchangchih is, at least, partly attributed to antcin A that mimics glucocorticoids and triggers translocation of glucocorticoid receptor into nucleus to initiate the suppressing inflammation.
Publisher
Nature Publishing Group UK,Nature Publishing Group
Subject
Anti-Inflammatory Agents - chemistry
/ Anti-Inflammatory Agents - isolation & purification
/ Anti-Inflammatory Agents - pharmacology
/ Biomedical and Life Sciences
/ Dexamethasone - pharmacology
/ Fruiting Bodies, Fungal - chemistry
/ Glucocorticoids - pharmacology
/ Humans
/ Original
/ Receptors, Glucocorticoid - metabolism
/ Steroids - isolation & purification
/ Vaccine
/ 分子对接
/ 化合物
/ 地塞米松
/ 抗炎作用
/ 樟芝
/ 模仿
/ 类激素
/ 糖皮质激素受体
