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NeuroExaminer: an all-glass microfluidic device for whole-brain in vivo imaging in zebrafish
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NeuroExaminer: an all-glass microfluidic device for whole-brain in vivo imaging in zebrafish
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Journal Article
NeuroExaminer: an all-glass microfluidic device for whole-brain in vivo imaging in zebrafish
2020
Overview
While microfluidics enables chemical stimuli application with high spatio-temporal precision, light-sheet microscopy allows rapid imaging of entire zebrafish brains with cellular resolution. Both techniques, however, have not been combined to monitor whole-brain neural activity yet. Unlike conventional microfluidics, we report here an all-glass device (NeuroExaminer) that is compatible with whole-brain in vivo imaging using light-sheet microscopy and can thus provide insights into brain function in health and disease.
Kai Mattern, Jakob W. von Trotha, et al. develop NeuroExaminer, an all glass device for whole-brain in vivo imaging in zebrafish. The method is based on light-sheet microscopy and microfluidics and provides insights on brain function in live zebrafish.
Publisher
Nature Publishing Group UK,Nature Publishing Group
Subject
