Journal Article

Compatibility of fosfomycin with different commercial peritoneal dialysis solutions

Pichler, P., Kussmann, M., Zeitlinger, M., Poeppl, W., Burgmann, H., Hauer, S., Wiesholzer, M., Reznicek, G., Baumann, A.

2017

Overview

For treatment of peritoneal dialysis-related peritonitis, intraperitoneal administration of antibiotics remains the preferable route. For home-based therapy, patients are commonly supplied with peritoneal dialysis fluids already containing antimicrobial agents. The present study set out to investigate the compatibility of fosfomycin with different peritoneal dialysis fluids, namely, Extraneal ® , Nutrineal ® , Physioneal ® 1.36% and Physioneal ® 2.27%, under varying storage conditions. The peritoneal dialysis fluid bags including 4 g fosfomycin were stored over 14 days at refrigeration temperature (6°C) and room temperature (25°C) and over 24 h at body temperature (37°C). Drug concentrations over time were determined by using high-performance liquid chromatography coupled to a mass spectrometer. In addition, drug activity was assessed by a disk diffusion method, diluent stability by visual inspection and drug adsorption by comparison of the measured and calculated concentrations. Blank peritoneal dialysis fluids and deionized water were used as comparator solutions. Fosfomycin was stable in all peritoneal dialysis fluids and at each storage condition investigated over the whole study period. The remaining drug concentrations ranged between 94% and 104% of the respective initial concentrations. No significant drug adsorption was observed for any peritoneal dialysis fluid at any storage condition. No relevant reduction of antimicrobial activity was observed. Fosfomycin is compatible with Extraneal ® , Nutrineal ® and Physioneal ® for up to two weeks at refrigeration or room temperature and may be used for home-based therapy. No dose adjustment is needed due to adsorption or degradation.

• Publisher: Springer Berlin Heidelberg,Springer Nature B.V
• Subject: Adsorption / Anti-Bacterial Agents - therapeutic use / Antibiotics / Antiinfectives and antibacterials / Antimicrobial activity / Antimicrobial agents / Biomedical and Life Sciences / Biomedicine / Body temperature / Compatibility / Deionization / Dialysis / Dialysis Solutions - therapeutic use / Disk Diffusion Antimicrobial Tests / Drug Interactions / Fluids / Fosfomycin / Fosfomycin - therapeutic use / Gram-Negative Bacteria - drug effects / Gram-Negative Bacterial Infections - drug therapy / Gram-Negative Bacterial Infections - microbiology / Gram-Positive Bacteria - drug effects / Gram-Positive Bacterial Infections - drug therapy / Gram-Positive Bacterial Infections - microbiology / High-performance liquid chromatography / Humans / Internal Medicine / Liquid chromatography / Medical Microbiology / Original / Original Article / Peritoneal dialysis / Peritoneal Dialysis - adverse effects / Peritoneal Dialysis - methods / Peritoneum / Peritonitis / Peritonitis - drug therapy / Peritonitis - microbiology / Refrigeration / Stability analysis / Storage conditions / Studies / Temperature effects / Therapy