Asset Details
Do you wish to reserve the book?
Assessment of the anti‐inflammatory and anti‐glycemic properties of Royal Jelly and Tocotrienol‐rich fraction in an experimental study: Does irisin mediate these effects?
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Assessment of the anti‐inflammatory and anti‐glycemic properties of Royal Jelly and Tocotrienol‐rich fraction in an experimental study: Does irisin mediate these effects?
Do you wish to request the book?
Assessment of the anti‐inflammatory and anti‐glycemic properties of Royal Jelly and Tocotrienol‐rich fraction in an experimental study: Does irisin mediate these effects?
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Assessment of the anti‐inflammatory and anti‐glycemic properties of Royal Jelly and Tocotrienol‐rich fraction in an experimental study: Does irisin mediate these effects?
2024
Overview
Irisin, a novel adipomyokine, has been proposed to be a therapeutic agent against obesity‐related metabolic disease. Royal Jelly (RJ) and tocotrienol‐rich fraction (TRF) are suggested to promote obesity and its related problems through potential mutual mechanistic pathways. This investigation intended to evaluate the glycemic and inflammation‐promoting effects of RJ, TRF, and their combinations to evaluate their synergic effects through irisin action in obese rats induced by a high‐fat diet (HFD) that underwent a calorie restriction diet (CRD). Fifty HFD‐fed obese rats received the following interventions: RJ, TRF, or RJ + TRF in combination with a CRD for eight consecutive weeks. After the investigation, body weight, fasting blood sugar (FBS), irisin, insulin, C‐reactive protein (CRP), interleukin‐6 (IL‐6), interleukin‐1 beta (IL‐1β), leptin, adiponectin, and insulin resistance (IR) were assessed. After 8 weeks of treatment, significant weight reduction was noticed in rats that received RJ and RJ + TRF related to the CRD rats (p < .001), although this reduction was not considerable in TRF‐treated rats. RJ and RJ + TRF supplementation markedly elevated irisin concentrations in CRD rats (p < .05), but TRF did not. Glycemic indices, inflammatory indices including IL‐1β and CRP levels, and leptin concentrations were significantly decreased after RJ, TRF, and their combinations were added to CRD (p < .05). According to the mediational analysis results, irisin mediated the promoting effects of RJ on glycemic hemostasis. Based on the results of this investigation, RJ and TRF are novel nutrients that have the potential to improve obesity‐related disorders. This research suggests that RJ exerts its beneficial glycemic regulatory effects through irisin. The important new findings of the present research are that Royal Jelly (RJ) remarkably elevates irisin concentrations in high‐fat diet (HFD)‐induced obese rats. Furthermore, irisin is probably the mediator of the promoting efficacy of RJ on glucose hemostasis in the obesity model. It is proposed that the effects of RJ and irisin on obesity‐induced metabolic disorders occur through common pathways, which include inducing thermogenesis through the browning of white adipose tissue (WAT), activation of brown adipose tissue, and increasing energy metabolism.
We currently cannot retrieve any items related to this title. Kindly check back at a later time.