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Treatment of central precocious puberty by GnRH analogs： long-term outcome in men
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Treatment of central precocious puberty by GnRH analogs： long-term outcome in men
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Journal Article
Treatment of central precocious puberty by GnRH analogs： long-term outcome in men
2008
Overview
In boys, central precocious puberty （CPP） is the appearance of secondary sex characteristics driven by pituitary gonadotropin secretion before the age of 9 years. In the last years, relevant improvements in the treatment of CPP have been achieved. Because CPP is rare in boys, the majority of papers on this issue focus on girls and do not address specific features of male patients regarding end results and safety. In the present paper, recent advances of CPP management with GnRH analogs in men are summarized. End results in untreated and treated patients are also reviewed by an analysis of the recently published literature on treatment of CPP in men. The available data indicate that therapy with GnRH analogs can improve final height into the range of target height without significant adverse short-term and long-term effects, but longer follow-up of larger series of patients is still required to draw definitive conclusions.
Publisher
Blackwell Publishing Ltd,Medknow Publications & Media Pvt. Ltd
Subject
/ Adult
/ Child
/ Dose-Response Relationship, Drug
/ GnRH
/ Gonadotropin-Releasing Hormone - analogs & derivatives
/ Gonadotropin-Releasing Hormone - therapeutic use
/ gonadotropin‐releasing hormone analog safety
/ gonadotropin‐releasing hormone analog treatment
/ Humans
/ Male
/ Puberty, Precocious - drug therapy
/ Puberty, Precocious - physiopathology
/ 青少年
/ 青春期早熟
