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Journal Article
Cardioprotection: Where to from here?
2017
Overview
The size of the myocardial infarction remains an important therapeutic target, because heart attack size correlates with mortality and heart failure. In this era, myocardial infarct size is reduced primarily by timely reperfusion of the infarct related coronary artery. Whereas numerous pre-clinical studies have shown that certain pharmacologic agents and therapeutic maneuvers reduce myocardial infarction size greater than reperfusion alone, very few of these therapies have translated to successful clinical trials or standard clinical use. In this review we discuss both the recent successes as well as recent disappointments, and describe some of the newer potential therapies from the preclinical literature that have not yet been tested in clinical trials.
Publisher
Springer US,Springer Nature B.V
Subject
Adrenergic beta-Antagonists - adverse effects
/ Adrenergic beta-Antagonists - therapeutic use
/ Animals
/ Cardiovascular Agents - adverse effects
/ Cardiovascular Agents - therapeutic use
/ Drug Evaluation, Preclinical
/ Humans
/ Hypothermia, Induced - adverse effects
/ Ischemic Preconditioning, Myocardial - adverse effects
/ Ischemic Preconditioning, Myocardial - methods
/ Medicine
/ Myocardial Infarction - mortality
/ Myocardial Infarction - pathology
/ Myocardial Infarction - physiopathology
/ Myocardial Infarction - therapy
/ Myocardial Reperfusion - adverse effects
/ Myocardial Reperfusion - methods
