Asset Details
Do you wish to reserve the book?
The need for speed: drivers and consequences of accelerated replication forks
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
The need for speed: drivers and consequences of accelerated replication forks
Do you wish to request the book?
The need for speed: drivers and consequences of accelerated replication forks
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
The need for speed: drivers and consequences of accelerated replication forks
2025
Overview
The modulation of DNA replication dynamics has emerged as a key area of study in understanding genome stability and its perturbations in various physiological and pathological contexts. Replication fork rate is influenced by a variety of factors, including DNA repair pathways, origin firing, chromatin organization, transcription, and oncogenic signaling. This review highlights recent findings on the molecular mechanisms driving replication fork acceleration, focusing on scenarios such as PARP inhibition, oncogene activation, depletion of replication factors, and defects in Okazaki fragment processing. We discuss how reduced origin firing, R-loop resolution, and metabolic changes contribute to fork rate modulation, as well as the involvement of innate immune signaling, particularly through pathways such as cGAS-STING and ISG15. Special attention is given to consequences of accelerated replication forks for genome stability and their role in disease progression, particularly cancer. By unraveling the molecular mechanisms of fork acceleration, this Mini Review underscores its critical role in shaping genome integrity and cellular homeostasis, providing insights into future research directions and therapeutic strategies.
A mini review explores molecular drivers of replication fork acceleration and their consequences for genome stability, innate immunity, and cancer.
