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Bi-phasic effect of gelatin in myogenesis and skeletal muscle regeneration

by Kamei, Ken-ichiro , Liu, Xiaoling , Yu, Qing , Chang, Xinyu , Zu, Er , Fujisaki, Hitomi , Ikejima, Takashi , Wang, Dan Ohtan , Li, Xiangru , Mizuno, Kazunori , Hayashi, Toshihiko , Hattori, Shunji , Ma, Xiaowei , Wang, Ziqi , Song, Xintong

in Biomedical materials / gelatin / Gelatin - metabolism / Gelatin - pharmacology / hormesis / il-6/tnfα / Muscle Development / Muscle function / Muscle, Skeletal - metabolism / Musculoskeletal system / Myogenesis / Neuromuscular diseases / nox2 / Reactive oxygen species / Reactive Oxygen Species - metabolism / Regeneration / ros / skeletal muscle regeneration / Tissue engineering / Wound Healing

2021

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Bi-phasic effect of gelatin in myogenesis and skeletal muscle regeneration

2021

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2021

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Journal Article

Bi-phasic effect of gelatin in myogenesis and skeletal muscle regeneration

Kamei, Ken-ichiro,

Liu, Xiaoling,

Yu, Qing,

Chang, Xinyu,

Zu, Er,

Fujisaki, Hitomi,

Ikejima, Takashi,

Wang, Dan Ohtan,

Li, Xiangru,

Mizuno, Kazunori,

Hayashi, Toshihiko,

Hattori, Shunji,

Ma, Xiaowei,

Wang, Ziqi,

Song, Xintong

2021

Overview

Skeletal muscle regeneration requires extracellular matrix (ECM) remodeling, including an acute and transient breakdown of collagen that produces gelatin. Although the physiological function of this process is unclear, it has inspired the application of gelatin to injured skeletal muscle for a potential pro-regenerative effect. Here, we investigated a bi-phasic effect of gelatin in skeletal muscle regeneration, mediated by the hormetic effects of reactive oxygen species (ROS). Low-dose gelatin stimulated ROS production from NADPH oxidase 2 (NOX2) and simultaneously upregulated the antioxidant system for cellular defense, reminiscent of the adaptive compensatory process during mild stress. This response triggered the release of the myokine IL-6, which stimulates myogenesis and facilitates muscle regeneration. By contrast, high-dose gelatin stimulated ROS overproduction from NOX2 and the mitochondrial chain complex, and ROS accumulation by suppressing the antioxidant system, triggering the release of TNFα, which inhibits myogenesis and regeneration. Our results have revealed a bi-phasic role of gelatin in regulating skeletal muscle repair mediated by intracellular ROS, the antioxidant system and cytokine (IL-6 and TNFα) signaling.

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Publisher

The Company of Biologists Ltd,The Company of Biologists

Subject

Biomedical materials

/ gelatin

/ Gelatin - metabolism

/ Gelatin - pharmacology

/ hormesis

/ il-6/tnfα

/ Muscle Development