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Lumboperitoneal shunt in idiopathic normal pressure hydrocephalus: a prospective controlled study
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Lumboperitoneal shunt in idiopathic normal pressure hydrocephalus: a prospective controlled study
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Lumboperitoneal shunt in idiopathic normal pressure hydrocephalus: a prospective controlled study
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Journal Article
Lumboperitoneal shunt in idiopathic normal pressure hydrocephalus: a prospective controlled study
2020
Overview
Objective
In this prospective, controlled, monocentric study, we described the clinical and neuroimaging 12-month follow-up of two parallel cohorts of subjects with idiopathic normal pressure hydrocephalus (iNPH), who did or did not undergo lumboperitoneal shunt (LPS).
Methods
We recruited 78 iNPH patients. At baseline, subjects underwent clinical and neuropsychological assessments, 3 T magnetic resonance imaging (MRI), and tap test. After baseline, 44 patients (LPS group) opted for LPS implantation, whereas 34 subjects (control group) declined surgery. Both cohorts were then followed up for 12 months through scheduled clinical and neuropsychological evaluations every 6 months. 3 T MRI was repeated at 12-month follow-up.
Results
Gait, balance, and urinary continence improved in the LPS group, without significant influence on cognitive functions. Conversely, gait and urinary continence worsened in the control group. No preoperative MRI parameter was significant outcome predictor after LPS. Of relevance, in responders to LPS, we found postoperative reduction of periventricular white matter (PWM) hyperintensities, which were instead increased in the control group.
Conclusions
LPS is safe and effective in iNPH. An early surgical treatment is desirable to prevent clinical worsening. Post-surgery decrease of PWM hyperintensities may be a useful MRI marker surrogate for clinical effectiveness of LPS.
Publisher
Springer Berlin Heidelberg,Springer Nature B.V
Subject
