Journal Article

Toxicology of deoxynivalenol and its acetylated and modified forms

Biomin Research Center, Loiseau, Nicolas, Biosynthèse & Toxicité des Mycotoxines (ToxAlim-BioToMyc) ; ToxAlim (ToxAlim) ; Institut National de la Recherche Agronomique (INRA)-Université Toulouse III - Paul Sabatier (UT3) ; Université de Toulouse (UT)-Université de Toulouse (UT)-Ecole Nationale Vétérinaire de Toulouse (ENVT) ; Institut National Polytechnique (Toulouse) (Toulouse INP) ; Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National Polytechnique (Toulouse) (Toulouse INP) ; Université de Toulouse (UT)-Ecole d'Ingénieurs de Purpan (INP - PURPAN) ; Institut National Polytechnique (Toulouse) (Toulouse INP) ; Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National de la Recherche Agronomique (INRA)-Université Toulouse III - Paul Sabatier (UT3) ; Université de Toulouse (UT)-Université de Toulouse (UT)-Ecole Nationale Vétérinaire de Toulouse (ENVT) ; Institut National Polytechnique (Toulouse) (Toulouse INP) ; Université de Toulouse (UT)-Université de To

2016

Overview

Mycotoxins are the most frequently occurring natural contaminants in human and animal diet. Among them, deoxynivalenol (DON), produced by Fusarium, is one of the most prevalent and thus represent an important health risk. Recent detection methods revealed new mycotoxins and new molecules derivated from the \"native\" mycotoxin. The main derivates of DON are the acetylated forms produced by the fungi (3-and 15acetyl-DON), the biologically \"modified\" forms produced by the plant (deoxynivalenol-3-β-D-glucopyranoside), or after bacteria transformation (de-epoxy DON, 3-epi-DON and 3-keto-DON) as well as the chemical \"modified\" forms (norDON A-C and DON-sulfonates). High proportions of acetylated and modified forms of DON co-occur with DON, increasing the exposure and the health risk. DON and its acetylated and modified forms are rapidly absorbed following ingestion. At the molecular level DON binds to the ribosome, induces a ribotoxic stress leading to the activation of MAP kinases, cellular cell-cycle arrest and apoptosis. The toxic effects of DON include emesis and anorexia, alteration of intestinal and immune functions, reduced absorption of the nutrients as well as increased susceptibility to infection and chronic diseases. In contrast to DON, very little information exists concerning the acetylated and modified forms; some can be converted back to DON, their ability to bind to the ribosome and to induce cellular effect varied according to the toxin. Except for the acetylated forms, their toxicity and impact on human and animal health are poorly documented.

• Publisher: Springer Verlag,CCSD,Springer Berlin Heidelberg,Springer Nature B.V
• Subject: Acetylation / Animal biology / Animal Feed - adverse effects / Animal Feed - analysis / Animal Feed - microbiology / Animals / Biological Availability / Biomedical and Life Sciences / Biomedicine / Biotransformation / Carcinogens, Environmental - chemistry / Carcinogens, Environmental - metabolism / Carcinogens, Environmental - toxicity / Contamination / Diet / Environmental Health / Food Contamination - prevention & control / Fusarium / Fusarium - metabolism / Glucosides - chemistry / Glucosides - metabolism / Glucosides - toxicity / Humans / Intestinal Absorption / Kinetics / Life Sciences / Molecular Conformation / Occupational Medicine/Industrial Medicine / Pharmacology/Toxicology / Renal Elimination / Review Article / Tissue Distribution / Toxicokinetics / Toxicology / Toxicology and food chain / Trichothecenes - chemistry / Trichothecenes - metabolism / Trichothecenes - toxicity / Vegetal toxicology and mycotoxicology / Veterinary medicine and animal Health
• ISBN: 0003876976000