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Recent Advances in the Clinical Translation of Silicon Fluoride Acceptor (SiFA) 18F-Radiopharmaceuticals

by Leonie Beyer , Lexi Gower-Fry , Yinglan Pu , Justin J. Bailey , Carolin Jaworski , Klaus Jurkschat , Ralf Schirrmacher , Carmen Wängler , Björn Wängler , Travis Kronemann , Peter Bartenstein , Andreas Dorian , Simon Lindner

in Cell division / Fluorides / Fluorine / fluorine-18 / Glucose / Labeling / Medical imaging / Medicine / Metabolism / Methods / Peptides / Pharmacy and materia medica / positron emission tomography (PET) / R / radiochemistry / Review / RS1-441 / silicon fluoride acceptor (SiFA) / Tumors

2021

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Recent Advances in the Clinical Translation of Silicon Fluoride Acceptor (SiFA) 18F-Radiopharmaceuticals

2021

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Recent Advances in the Clinical Translation of Silicon Fluoride Acceptor (SiFA) 18F-Radiopharmaceuticals

2021

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Journal Article

Recent Advances in the Clinical Translation of Silicon Fluoride Acceptor (SiFA) 18F-Radiopharmaceuticals

Leonie Beyer,

Lexi Gower-Fry,

Yinglan Pu,

Justin J. Bailey,

Carolin Jaworski,

Klaus Jurkschat,

Ralf Schirrmacher,

Carmen Wängler,

Björn Wängler,

Travis Kronemann,

Peter Bartenstein,

Andreas Dorian,

Simon Lindner

2021

Overview

The incorporation of silicon fluoride acceptor (SiFA) moieties into a variety of molecules, such as peptides, proteins and biologically relevant small molecules, has improved the generation of 18F-radiopharmaceuticals for medical imaging. The efficient isotopic exchange radiofluorination process, in combination with the enhanced [18F]SiFA in vivo stability, make it a suitable strategy for fluorine-18 incorporation. This review will highlight the clinical applicability of [18F]SiFA-labeled compounds and discuss the significant radiotracers currently in clinical use.

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MDPI AG,MDPI

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/ Glucose