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Patient experience and quality of life during neoadjuvant therapy for pancreatic cancer: a systematic review and study protocol
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Patient experience and quality of life during neoadjuvant therapy for pancreatic cancer: a systematic review and study protocol
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Journal Article
Patient experience and quality of life during neoadjuvant therapy for pancreatic cancer: a systematic review and study protocol
2021
Overview
PurposeNeoadjuvant therapy (NT) is increasingly being offered to patients with pancreatic ductal adenocarcinoma (PDAC) prior to surgical resection. However, the experience and quality of life (QOL) of patients undergoing NT are poorly understood.MethodsA systematic review of the Cinahl, Embase, Medline, Pubmed, Scopus, and Web of Science databases was conducted to evaluate the available literature pertaining to the experience and QOL of patient’s undergoing NT for PDAC.ResultsAmong 6041 articles screened, only six met criteria for full-text review including three prospective clinical trials of NT with QOL secondary endpoints. Overall, global QOL during or following NT did not significantly change from baseline. Pain scores seemed to improve during NT while the impact of NT on physical functioning varied across studies. No studies were identified evaluating other aspects of the patient experience.ConclusionAlthough NT appears to have a minor impact on the QOL of patients with PDAC, this systematic review identified significant evidence gaps in the literature. A protocol of a prospective observational cohort study utilizing a digital smartphone app that aims to evaluate the patient experience and longitudinal QOL of patients with PDAC undergoing NT is presented.
Publisher
Springer Nature B.V
