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Dairy Consumption and Body Mass Index Among Adults: Mendelian Randomization Analysis of 184802 Individuals from 25 Studies

by Rich, Stephen S , Ericson, Ulrika , Aslibekyan, Stella , Wang, Yujie , Arnett, Donna K , Franco, Oscar H , Renström, Frida , Rotter, Jerome I , Pedersen, Oluf , Wang, Tiange , Lai, Chao-Qiang , Pennell, Craig E , Ridker, Paul M , Toft, Ulla , Schulz, Christina-Alexandra , Sorlí, Jose V , Tucker, Katherine L , Chasman, Daniel I , Tanaka, Toshiko , Graff, Mariaelisa , Allison, Mathew A , Heianza, Yoriko , Lemaitre, Rozenn N , Coltell, Oscar , Chen, Tzu-An , Raitakari, Olli , Varbo, Anette , Wojczynski, Mary K , van Rooij, Frank J A , Hansen, Torben , Lehtimäki, Terho , Voortman, Trudy , Mozaffarian, Dariush , North Kari, E , Sonestedt, Emily , Uitterlinden, Andre G , Province, Michael A , Hu, Frank B , Qi, Lu , Zillikens, M Carola , Hofman, Albert , Hernandez, Dena , Bergholdt Helle, K M , Kähönen, Mika , de Jonge, M Ester A L , Orho-Melander, Marju , Barroso, Inês , Huang, Tao , Ordovas, Jose M , Fumeron, Frédéric , Linneberg, Allan , Frazier-Wood Alexis, C , Corella, Dolores , Johansson, Ingegerd , Mikkilä, Vera , Franks, Paul W , Ferrucci, Luigi , Overvad, Kim , Sørensen, Thorkild I A , Psaty, Bruce M , Siscovick, David S , Bandinelli, Stefania , Kilpeläinen, Tuomas

in Adults / Body mass index / Body size / Epidemiology / Gene polymorphism / Genotypes / Health risk assessment / Lactase / Obesity / Polymorphism / Randomization / Regression analysis / Regression models / Systematic review

2018

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Dairy Consumption and Body Mass Index Among Adults: Mendelian Randomization Analysis of 184802 Individuals from 25 Studies

2018

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2018

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Journal Article

Dairy Consumption and Body Mass Index Among Adults: Mendelian Randomization Analysis of 184802 Individuals from 25 Studies

Rich, Stephen S,

Ericson, Ulrika,

Aslibekyan, Stella,

Wang, Yujie,

Arnett, Donna K,

Franco, Oscar H,

Renström, Frida,

Rotter, Jerome I,

Pedersen, Oluf,

Wang, Tiange,

Lai, Chao-Qiang,

Pennell, Craig E,

Ridker, Paul M,

Toft, Ulla,

Schulz, Christina-Alexandra,

Sorlí, Jose V,

Tucker, Katherine L,

Chasman, Daniel I,

Tanaka, Toshiko,

Graff, Mariaelisa,

Allison, Mathew A,

Heianza, Yoriko,

Lemaitre, Rozenn N,

Coltell, Oscar,

Chen, Tzu-An,

Raitakari, Olli,

Varbo, Anette,

Wojczynski, Mary K,

van Rooij, Frank J A,

Hansen, Torben,

Lehtimäki, Terho,

Voortman, Trudy,

Mozaffarian, Dariush,

North Kari, E,

Sonestedt, Emily,

Uitterlinden, Andre G,

Province, Michael A,

Hu, Frank B,

Qi, Lu,

Zillikens, M Carola,

Hofman, Albert,

Hernandez, Dena,

Bergholdt Helle, K M,

Kähönen, Mika,

de Jonge, M Ester A L,

Orho-Melander, Marju,

Barroso, Inês,

Huang, Tao,

Ordovas, Jose M,

Fumeron, Frédéric,

Linneberg, Allan,

Frazier-Wood Alexis, C,

Corella, Dolores,

Johansson, Ingegerd,

Mikkilä, Vera,

Franks, Paul W,

Ferrucci, Luigi,

Overvad, Kim,

Sørensen, Thorkild I A,

Psaty, Bruce M,

Siscovick, David S,

Bandinelli, Stefania,

Kilpeläinen, Tuomas

2018

Overview

Associations between dairy intake and body mass index (BMI) have been inconsistently observed in epidemiological studies, and the causal relationship remains ill defined. We performed Mendelian randomization (MR) analysis using an established dairy intake-associated genetic polymorphism located upstream of the lactase gene ( -13910 C/T, rs4988235) as an instrumental variable (IV). Linear regression models were fitted to analyze associations between ( ) dairy intake and BMI, ( ) rs4988235 and dairy intake, and ( ) rs4988235 and BMI in each study. The causal effect of dairy intake on BMI was quantified by IV estimators among 184802 participants from 25 studies. Higher dairy intake was associated with higher BMI (β = 0.03 kg/m per serving/day; 95% CI, 0.00-0.06; = 0.04), whereas the genotype with 1 or 2 T allele was significantly associated with 0.20 (95% CI, 0.14-0.25) serving/day higher dairy intake ( = 3.15 × 10 ) and 0.12 (95% CI, 0.06-0.17) kg/m higher BMI ( = 2.11 × 10 ). MR analysis showed that the genetically determined higher dairy intake was significantly associated with higher BMI (β = 0.60 kg/m per serving/day; 95% CI, 0.27-0.92; = 3.0 × 10 ). The present study provides strong evidence to support a causal effect of higher dairy intake on increased BMI among adults.

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Publisher

Oxford University Press

Subject

/ Health risk assessment