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Low‐frequency rTMS targeting individual self‐initiated finger‐tapping task activation modulates the amplitude of local neural activity in the putamen
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Low‐frequency rTMS targeting individual self‐initiated finger‐tapping task activation modulates the amplitude of local neural activity in the putamen
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Low‐frequency rTMS targeting individual self‐initiated finger‐tapping task activation modulates the amplitude of local neural activity in the putamen
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Journal Article
Low‐frequency rTMS targeting individual self‐initiated finger‐tapping task activation modulates the amplitude of local neural activity in the putamen
2023
Overview
Repetitive transcranial magnetic stimulation (rTMS) has been used in the clinical treatment of Parkinson's disease (PD). Most of rTMS studies on PD used high‐frequency stimulation; however, excessive nonvoluntary movement may represent abnormally cortical excitability, which is likely to be suppressed by low‐frequency rTMS. Decreased neural activity in the basal ganglia on functional magnetic resonance imaging (fMRI) is a characteristic of PD. In the present study, we found that low‐frequency (1 Hz) rTMS targeting individual finger‐tapping activation elevated the amplitude of local neural activity (percentage amplitude fluctuation, PerAF) in the putamen as well as the functional connectivity (FC) of the stimulation target and basal ganglia in healthy participants. These results provide evidence for our hypothesis that low‐frequency rTMS over the individual task activation site can modulate deep brain functions, and that FC might serve as a bridge transmitting the impact of rTMS to the deep brain regions. It suggested that a precisely localized individual task activation site can act as a target for low‐frequency rTMS when it is used as a therapeutic tool for PD. A “Steady‐state” paradigm of finger‐tapping task detected that self‐initiated finger‐tapping was more intensively associated with the motor‐related brain area than visual‐guided. Low‐frequency rTMS targeting individual task peak activation could precisely elevated the local neural activity in the putamen. The basal ganglia neural activity may be sensitive to low‐frequency rTMS and the excessive nonvoluntary movement of PD is likely to be suppressed by low‐frequency rTMS rather than high frequency.
Publisher
John Wiley & Sons, Inc
