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Dicer1–miR-328–Bace1 signalling controls brown adipose tissue differentiation and function
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Dicer1–miR-328–Bace1 signalling controls brown adipose tissue differentiation and function
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Journal Article
Dicer1–miR-328–Bace1 signalling controls brown adipose tissue differentiation and function
2016
Overview
Kornfeld and colleagues identify miRNAs that are dysregulated in brown adipose tissue in mouse models of obesity and ageing, and show that miR-328 targets Bace1 to promote brown adipogenesis.
Activation of brown adipose tissue (BAT) controls energy homeostasis in rodents and humans and has emerged as an innovative strategy for the treatment of obesity and type 2 diabetes mellitus
1
,
2
,
3
,
4
. Here we show that ageing- and obesity-associated dysfunction of brown fat coincides with global microRNA downregulation due to reduced expression of the microRNA-processing node Dicer1. Consequently, heterozygosity of
Dicer1
in BAT aggravated diet-induced-obesity (DIO)-evoked deterioration of glucose metabolism. Analyses of differential microRNA expression during preadipocyte commitment and mouse models of progeria, longevity and DIO identified miR-328 as a regulator of BAT differentiation. Reducing miR-328 blocked preadipocyte commitment, whereas miR-328 overexpression instigated BAT differentiation and impaired muscle progenitor commitment—partly through silencing of the β-secretase Bace1. Loss of Bace1 enhanced brown preadipocyte specification
in vitro
and was overexpressed in BAT of obese and progeroid mice.
In vivo
Bace1 inhibition delayed DIO-induced weight gain and improved glucose tolerance and insulin sensitivity. These experiments reveal Dicer1–miR-328–Bace1 signalling as a determinant of BAT function, and highlight the potential of Bace1 inhibition as a therapeutic approach to improve not only neurodegenerative diseases but also ageing- and obesity-associated impairments of BAT function.
Publisher
Nature Publishing Group UK,Nature Publishing Group
Subject
/ Adipose Tissue, Brown - metabolism
/ Aging
/ Amyloid Precursor Protein Secretases - genetics
/ Amyloid Precursor Protein Secretases - metabolism
/ Animals
/ Aspartic Acid Endopeptidases - genetics
/ Aspartic Acid Endopeptidases - metabolism
/ Biology
/ Body fat
/ Cell Differentiation - physiology
/ Cellular signal transduction
/ DEAD-box RNA Helicases - genetics
/ DEAD-box RNA Helicases - metabolism
/ Diabetes
/ Energy Metabolism - physiology
/ Glucose
/ Insulin Resistance - physiology
/ letter
/ MicroRNA
/ Obesity
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