Asset Details
Do you wish to reserve the book?
Cancer Microenvironment Defines Tumor-Infiltrating Lymphocyte Density and Tertiary Lymphoid Structure Formation in Laryngeal Cancer
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Cancer Microenvironment Defines Tumor-Infiltrating Lymphocyte Density and Tertiary Lymphoid Structure Formation in Laryngeal Cancer
Do you wish to request the book?
Cancer Microenvironment Defines Tumor-Infiltrating Lymphocyte Density and Tertiary Lymphoid Structure Formation in Laryngeal Cancer
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Cancer Microenvironment Defines Tumor-Infiltrating Lymphocyte Density and Tertiary Lymphoid Structure Formation in Laryngeal Cancer
2023
Overview
Background
The presence and activity of tumor-infiltrating lymphocytes (TILs) is a key parameter related to the antitumor immune response. A large number of studies reveal TIL density as a prognostic marker and predictor of response to radiotherapy, chemotherapy, and immunotherapy.
Methods
We examined the TIL and tertiary lymphoid structure TLS density in the invading front and inner tumor stroma, in a 33 squamous cell laryngeal carcinomas (LSCC) treated with laryngectomy. TIL and TLS densities were in parallel examined with markers of anaerobic metabolism, vascular density (VD), vascular survival ability (VSA), and histopathological parameters.
Results
TIL and TLS densities significantly decreased in inner tumor areas (
p
< 0.0001). TIL density in the invading tumor front was inversely related with lymph node involvement (
p
= 0.03), HIF1α expression (
p
= 0.008), vessel density (
p
= 0.02), and MIB1 (
p
= 0.006). TIL density in inner stroma was inversely linked to local invasion (marginal
p
= 0.05), tumor budding (TB) (
p
= 0.005), MIB1 (
p
= 0.02), and HIF1α expression (
p
= 0.02). Low-TLS density in the invading front and in inner tumor areas was related to high TB (
p
= 0.02 and 0.002, respectively), HIF1α (
p
= 0.003 and 0.01, respectively), and LDH5 expression (
p
= 0.003 and 0.007, respectively). CD4
+
, FOXP3
+
TIL density, and FOXP3
+
/CD8
+
ratio were directly associated with VSA (
p
= 0.008, 0.02, and 0.05, respectively).
Conclusion
Poor immune response is related to hypoxic background and anaerobic metabolism, as well as increased invasive and metastatic ability. Regulatory TIL markers are linked with increased angiogenic potential. The prognostic, predictive, and therapy-guiding value of TILs in clinical practice demands thorough investigation.
Publisher
Springer US,Springer Nature B.V
