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Maturation strategies and limitations of induced pluripotent stem cell-derived cardiomyocytes
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Maturation strategies and limitations of induced pluripotent stem cell-derived cardiomyocytes
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Journal Article
Maturation strategies and limitations of induced pluripotent stem cell-derived cardiomyocytes
2021
Overview
Induced pluripotent stem cells (iPSCs) have the ability to differentiate into cardiomyocytes (CMs). They are not only widely used in cardiac pharmacology screening, human heart disease modeling, and cell transplantation-based treatments, but also the most promising source of CMs for experimental and clinical applications. However, their use is largely restricted by the immature phenotype of structure and function, which is similar to embryonic or fetal CMs and has certain differences from adult CMs. In order to overcome this critical issue, many studies have explored and revealed new strategies to induce the maturity of iPSC-CMs. Therefore, this article aims to review recent induction methods of mature iPSC-CMs, related mechanisms, and limitations.
Publisher
Portland Press Ltd The Biochemical Society,Portland Press Ltd
Subject
