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Impact of Visceral and Hepatic Fat on Cardiometabolic Health
by
Nied, Matthew
, Khawaja, Tasveer
, Neeland, Ian J.
, Wilgor, Abigail
in
Body Fat Distribution
/ Cardiology
/ Cardiometabolic Disease (DM and CV) (CJ Lavie
/ Cardiometabolic Disease (DM and CV) (CJ Lavie, Section Editor)
/ Cardiometabolic Risk Factors
/ Cardiovascular Diseases - prevention & control
/ Diabetes Mellitus, Type 2 - complications
/ Diabetes Mellitus, Type 2 - physiopathology
/ Glucagon-Like Peptide-1 Receptor Agonists
/ Humans
/ Intra-Abdominal Fat
/ Liver - metabolism
/ Medicine
/ Medicine & Public Health
/ Obesity - complications
/ Obesity - physiopathology
/ Section Editor
/ Sodium-Glucose Transporter 2 Inhibitors - therapeutic use
/ Topical Collection on Cardiometabolic Disease (DM and CV)
/ Weight Loss
2024
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Impact of Visceral and Hepatic Fat on Cardiometabolic Health
by
Nied, Matthew
, Khawaja, Tasveer
, Neeland, Ian J.
, Wilgor, Abigail
in
Body Fat Distribution
/ Cardiology
/ Cardiometabolic Disease (DM and CV) (CJ Lavie
/ Cardiometabolic Disease (DM and CV) (CJ Lavie, Section Editor)
/ Cardiometabolic Risk Factors
/ Cardiovascular Diseases - prevention & control
/ Diabetes Mellitus, Type 2 - complications
/ Diabetes Mellitus, Type 2 - physiopathology
/ Glucagon-Like Peptide-1 Receptor Agonists
/ Humans
/ Intra-Abdominal Fat
/ Liver - metabolism
/ Medicine
/ Medicine & Public Health
/ Obesity - complications
/ Obesity - physiopathology
/ Section Editor
/ Sodium-Glucose Transporter 2 Inhibitors - therapeutic use
/ Topical Collection on Cardiometabolic Disease (DM and CV)
/ Weight Loss
2024
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Impact of Visceral and Hepatic Fat on Cardiometabolic Health
by
Nied, Matthew
, Khawaja, Tasveer
, Neeland, Ian J.
, Wilgor, Abigail
in
Body Fat Distribution
/ Cardiology
/ Cardiometabolic Disease (DM and CV) (CJ Lavie
/ Cardiometabolic Disease (DM and CV) (CJ Lavie, Section Editor)
/ Cardiometabolic Risk Factors
/ Cardiovascular Diseases - prevention & control
/ Diabetes Mellitus, Type 2 - complications
/ Diabetes Mellitus, Type 2 - physiopathology
/ Glucagon-Like Peptide-1 Receptor Agonists
/ Humans
/ Intra-Abdominal Fat
/ Liver - metabolism
/ Medicine
/ Medicine & Public Health
/ Obesity - complications
/ Obesity - physiopathology
/ Section Editor
/ Sodium-Glucose Transporter 2 Inhibitors - therapeutic use
/ Topical Collection on Cardiometabolic Disease (DM and CV)
/ Weight Loss
2024
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Impact of Visceral and Hepatic Fat on Cardiometabolic Health
Journal Article
Impact of Visceral and Hepatic Fat on Cardiometabolic Health
2024
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Overview
Purpose of Review
Body fat distribution plays a significant role in the cardiometabolic consequences of obesity. We review the impact of visceral and hepatic fat and highlight important interventions.
Recent Findings
Several epidemiologic studies have established a clear association between visceral fat and cardiovascular disease. The association between hepatic fat and cardiovascular disease is less clear with discordant results. Novel evidence demonstrates sodium glucose co-transporter-2 (SGLT2) inhibitors facilitate modest weight loss and reductions in ectopic fat depots in patient with type 2 diabetes. Glucagon-like peptide-1 (GLP-1) receptor agonists have been associated with decreased visceral/hepatic fat and reductions in MACE in populations with type 2 diabetes and with overweight/obesity.
Summary
Clear associations between visceral fat and cardiometabolic outcomes have been established, whereas the impact of hepatic fat remains less clear. Lifestyle modification and pharmacologic interventions remain the initial therapies, while surgical intervention is associated with improved long-term outcomes. Emerging therapies have demonstrated a profound impact on body fat distribution and cardiometabolic risk.
Publisher
Springer US,Springer Nature B.V
Subject
/ Cardiometabolic Disease (DM and CV) (CJ Lavie
/ Cardiometabolic Disease (DM and CV) (CJ Lavie, Section Editor)
/ Cardiometabolic Risk Factors
/ Cardiovascular Diseases - prevention & control
/ Diabetes Mellitus, Type 2 - complications
/ Diabetes Mellitus, Type 2 - physiopathology
/ Glucagon-Like Peptide-1 Receptor Agonists
/ Humans
/ Medicine
/ Sodium-Glucose Transporter 2 Inhibitors - therapeutic use
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