Journal Article

Advancing genomics to improve health equity

Kittles, Rick A., Pérez-Stable, Eliseo J., Fletcher, Faith E., Hindorff, Lucia A., Hildreth, James E. K., Lee, Sandra S.-J., Wojcik, Genevieve L., Di Francesco, Valentina, Wilfond, Benjamin S., Inouye, Michael, Dillard, Denise A., Jackson, Amber, Fullerton, Stephanie M., Burchard, Esteban G., Begay, Rene L., Garrison, Nanibaa’ A., Cho, Judy H., Baker, Kellan E., Hughes Halbert, Chanita A., Ofili, Elizabeth O., Schools, Lorjetta E., Green, Eric D., Limdi, Nita A., Leek, Jeff T., Saulsberry, Loren, Hammack-Aviran, Catherine M., Sabatello, Maya, Landry, Latrice G., Carpten, John D., Troyer, Jennifer L., Horowitz, Carol R., Cox, Nancy J., Lockhart, Nicole C., Bonham, Vence L., Akintobi, Tabia Henry, Madden, Ebony B., Hiratsuka, Vanessa Y.

2024

Overview

Health equity is the state in which everyone has fair and just opportunities to attain their highest level of health. The field of human genomics has fallen short in increasing health equity, largely because the diversity of the human population has been inadequately reflected among participants of genomics research. This lack of diversity leads to disparities that can have scientific and clinical consequences. Achieving health equity related to genomics will require greater effort in addressing inequities within the field. As part of the commitment of the National Human Genome Research Institute (NHGRI) to advancing health equity, it convened experts in genomics and health equity research to make recommendations and performed a review of current literature to identify the landscape of gaps and opportunities at the interface between human genomics and health equity research. This Perspective describes these findings and examines health equity within the context of human genomics and genomic medicine. This Perspective discusses how addressing disparities in genomics can drive improvements in health equity more broadly.

• Publisher: Nature Publishing Group US,Nature Publishing Group
• Subject: 631/208/212 / 692/308/2056 / Agriculture / Animal Genetics and Genomics / Biomedical and Life Sciences / Biomedicine / Cancer Research / Disease / Funding / Gene Function / Genome, Human / Genomes / Genomics / Genomics - methods / Health disparities / Health Equity / Human Genetics / Human populations / Humans / Inclusion / Literature reviews / Medicine / Multiculturalism & pluralism / National Human Genome Research Institute (U.S.) / Perspective / Race / Racism / Research methodology / Socioeconomic factors / Underserved populations / United States / Workplace diversity