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Nedd4 and Nedd4-2: closely related ubiquitin-protein ligases with distinct physiological functions

by Yang, B , Kumar, S

in 14-3-3 Proteins - metabolism / Apoptosis / Biochemistry / Biomedical and Life Sciences / Cell Biology / Cell Cycle Analysis / Cell death / Endosomal Sorting Complexes Required for Transport - classification / Endosomal Sorting Complexes Required for Transport - metabolism / Endosomal Sorting Complexes Required for Transport - physiology / Enzymes / Epithelial Sodium Channels - metabolism / Human papillomavirus / Immediate-Early Proteins - metabolism / Kinases / Life Sciences / Nedd4 Ubiquitin Protein Ligases / Neuromuscular Junction - physiology / Physiology / Protein Serine-Threonine Kinases - metabolism / Proteins / PTEN Phosphohydrolase - metabolism / review / Saccharomyces cerevisiae / Saccharomyces cerevisiae Proteins - metabolism / Saccharomyces cerevisiae Proteins - physiology / Sodium Channels - metabolism / Stem Cells / Ubiquitin-Protein Ligase Complexes - metabolism / Ubiquitin-Protein Ligase Complexes - physiology / Ubiquitin-Protein Ligases - classification / Ubiquitin-Protein Ligases - metabolism / Ubiquitin-Protein Ligases - physiology / Ubiquitination

2010

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Nedd4 and Nedd4-2: closely related ubiquitin-protein ligases with distinct physiological functions

by Yang, B , Kumar, S

2010

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Nedd4 and Nedd4-2: closely related ubiquitin-protein ligases with distinct physiological functions

by Yang, B , Kumar, S

2010

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Journal Article

Nedd4 and Nedd4-2: closely related ubiquitin-protein ligases with distinct physiological functions

Yang, B,

Kumar, S

2010

Overview

The Nedd4 ( n eural precursor cell- e xpressed d evelopmentally d ownregulated gene 4) family of ubiquitin ligases (E3s) is characterized by a distinct modular domain architecture, with each member consisting of a C2 domain, 2–4 WW domains, and a HECT-type ligase domain. Of the nine mammalian members of this family, Nedd4 and its close relative, Nedd4-2, represent the ancestral ligases with strong similarity to the yeast, Rsp5. In Saccharomyces cerevisiae Rsp5 has a key role in regulating the trafficking, sorting, and degradation of a large number of proteins in multiple cellular compartments. However, in mammals the Nedd4 family members, including Nedd4 and Nedd4-2, appear to have distinct functions, thereby suggesting that these E3s target specific proteins for ubiquitylation. In this article we focus on the biology and emerging functions of Nedd4 and Nedd4-2, and review recent in vivo studies on these E3s.

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Publisher

Nature Publishing Group UK,Nature Publishing Group

Subject

14-3-3 Proteins - metabolism

/ Apoptosis

/ Biochemistry

/ Biomedical and Life Sciences

/ Cell Biology

/ Cell Cycle Analysis

/ Cell death