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Characterization of Ovine Intervertebral Disc Health Across the Lifespan: Relationships Between Quantitative MRI, Radiological, Histological, Biochemical, and Biomechanical Assessments
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Characterization of Ovine Intervertebral Disc Health Across the Lifespan: Relationships Between Quantitative MRI, Radiological, Histological, Biochemical, and Biomechanical Assessments
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Journal Article
Characterization of Ovine Intervertebral Disc Health Across the Lifespan: Relationships Between Quantitative MRI, Radiological, Histological, Biochemical, and Biomechanical Assessments
2026
Overview
Background Intervertebral disc (IVD) degeneration contributes significantly to chronic low back pain and represents a major clinical challenge. Quantitative MRI (qMRI) techniques offer the potential to assess biochemical and structural disc changes noninvasively, but its use has been slow to be incorporated into studies utilizing spontaneous large animal models. This study characterizes qMRI‐derived biomarkers of IVD degeneration across the lifespan in a clinically relevant ovine model. Methods Ex vivo thoracolumbar spine segments from 10 sheep (13–130 months old) were assessed using 3T MRI, including T2, T2*, T1ρ, adiabatic T1ρ, adiabatic T2ρ, and ADC mapping. Relaxation times were compared with Pfirrmann grade, disc height index, biomechanical testing, GAG/water content, and histological scores. Results T2 and T2* values in the nucleus pulposus (NP) were negatively correlated with age, Pfirrmann grade, and histological degeneration, and positively correlated with GAG and water content. T2 relaxation times in the annulus fibrosus (AF) were inversely related to biomechanical stiffness, whereas T2* relaxation times in the NP were positively associated. Strong inter‐metric correlations were observed between most qMRI measures, but aT1ρ and ADC showed more distinct profiles. Conclusion These findings support the sensitivity of qMRI in detecting regional and age‐related IVD changes and reinforce its utility for noninvasive disc assessment in translational models of degeneration. Quantitative MRI reveals age‐related degeneration of lumbar intervertebral discs. Axial T2 and T2* relaxation time maps from representative young (15‐month) and old (130‐month) sheep demonstrate substantially higher relaxation times in young discs, particularly within the nucleus pulposus, indicating a well‐hydrated and proteoglycan‐rich matrix. In contrast, older discs exhibit markedly reduced relaxation times consistent with dehydration and matrix degeneration. These imaging biomarkers highlight the sensitivity of T2 and T2* mapping for detecting age‐related changes in disc composition.
Publisher
John Wiley & Sons, Inc,Wiley
Subject
