Asset Details

MbrlCatalogueTitleDetail

Do you wish to reserve the book?

Antibody-functionalized gold nanoparticles as tumor-targeting radiosensitizers for proton therapy

by Martinive, Philippe , Bouchy, Sandra , Lucas, Stéphane , Li, Sha , Fichera, Ornella , Heuskin, Anne-Catherine , Marega, Riccardo , Penninckx, Sebastien , Gallez, Bernard , Feron, Olivier , Michiels, Carine

in Breast cancer / Cancer therapies / Charged particles / EGFR / gold nanoparticles / Monoclonal antibodies / nanoparticle uptake / Nanoparticles / protontherapy / Radiation therapy / radiosentizing effects / Studies / Targeted cancer therapy / X-rays

2019

Yes Please

Hey, we have placed the reservation for you!

By the way, why not check out events that you can attend while you pick your title.

Oops! Something went wrong.

Looks like we were not able to place the reservation. Kindly try again later.

Are you sure you want to remove the book from the shelf?

Antibody-functionalized gold nanoparticles as tumor-targeting radiosensitizers for proton therapy

2019

Confirm

Do you wish to request the book?

Antibody-functionalized gold nanoparticles as tumor-targeting radiosensitizers for proton therapy

2019

Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy

How would you like to get it?

Submit

We have requested the book for you!

Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.

Oops! Something went wrong.

Looks like we were not able to place your request. Kindly try again later.

Journal Article

Antibody-functionalized gold nanoparticles as tumor-targeting radiosensitizers for proton therapy

Martinive, Philippe,

Bouchy, Sandra,

Lucas, Stéphane,

Li, Sha,

Fichera, Ornella,

Heuskin, Anne-Catherine,

Marega, Riccardo,

Penninckx, Sebastien,

Gallez, Bernard,

Feron, Olivier,

Michiels, Carine

2019

Overview

This study aimed at developing antibody-functionalized gold nanoparticles (AuNPs) to selectively target cancer cells and probing their potential radiosensitizing effects under proton irradiation. AuNPs were conjugated with cetuximab (Ctxb-AuNPs). Ctxb-AuNP uptake was evaluated by transmission electron microscopy and atomic absorption spectroscopy. Radioenhancing effect was assessed using conventional clonogenic assay. Ctxb-AuNPs specifically bound to and accumulated in EGFR-overexpressing A431 cells, compared with EGFR-negative MDA-MB-453 cells. Ctxb-AuNPs enhanced the effect of proton irradiation in A431 cells but not in MDA-MB-453 cells. These data indicate, for the first time, that combining enhanced uptake by specific targeting and radioenhancing effect, using conjugated AuNPs, is a promising strategy to increase cell killing by protontherapy.

Share this book

Add to My Shelf

Publisher

Future Medicine Ltd

Subject

/ EGFR

/ Monoclonal antibodies

/ nanoparticle uptake