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Journal Article
An important role for triglyceride in regulating spermatogenesis
2024
Overview
Drosophila
is a powerful model to study how lipids affect spermatogenesis. Yet, the contribution of neutral lipids, a major lipid group which resides in organelles called lipid droplets (LD), to sperm development is largely unknown. Emerging evidence suggests LD are present in the testis and that loss of neutral lipid- and LD-associated genes causes subfertility; however, key regulators of testis neutral lipids and LD remain unclear. Here, we show LD are present in early-stage somatic and germline cells within the
Drosophila
testis. We identified a role for triglyceride lipase
brummer
(
bmm
) in regulating testis LD, and found that whole-body loss of
bmm
leads to defects in sperm development. Importantly, these represent cell-autonomous roles for
bmm
in regulating testis LD and spermatogenesis. Because lipidomic analysis of
bmm
mutants revealed excess triglyceride accumulation, and spermatogenic defects in
bmm
mutants were rescued by genetically blocking triglyceride synthesis, our data suggest that
bmm
-mediated regulation of triglyceride influences sperm development. This identifies triglyceride as an important neutral lipid that contributes to
Drosophila
sperm development, and reveals a key role for
bmm
in regulating testis triglyceride levels during spermatogenesis.
Publisher
eLife Sciences Publications Ltd,eLife Sciences Publications, Ltd
