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Antidepressant Augmentation versus Switch in Treatment-Resistant Geriatric Depression

by Lenze, Eric J. , Karp, Jordan F. , Pham, Vy T. , Brown, Patrick J. , Miller, J. Philip , Oughli, Hanadi A. , Roose, Steven P. , Gebara, Marie A. , Lenard, Emily , Flint, Alastair J. , Yang, Lei , Mulsant, Benoit H. , Lavretsky, Helen , Nicol, Ginger E. , Reynolds, Charles F. , Cristancho, Pilar , Blumberger, Daniel M. , Gettinger, Torie R. , Rollman, Bruce L.

in Aged / Aging / Aging General / Antidepressants / Antidepressive Agents - adverse effects / Antidepressive Agents - therapeutic use / Aripiprazole / Aripiprazole - adverse effects / Aripiprazole - therapeutic use / Bupropion / Bupropion - adverse effects / Bupropion - therapeutic use / Clinical Medicine / Clinical Medicine General / Depression / Design / Drug dosages / Drug Therapy, Combination / Geriatric psychiatry / Geriatrics / Humans / Life satisfaction / Lithium / Lithium Compounds - adverse effects / Lithium Compounds - therapeutic use / Mental depression / Neurology / Neurosurgery / Neurosurgery General / Nortriptyline - adverse effects / Nortriptyline - therapeutic use / Older people / Patient-centered care / Patients / Primary care / Psychiatry / Remission / Remission (Medicine) / Treatment resistance / Treatment Switching / Well being

2023

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Antidepressant Augmentation versus Switch in Treatment-Resistant Geriatric Depression

2023

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2023

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Journal Article

Antidepressant Augmentation versus Switch in Treatment-Resistant Geriatric Depression

Lenze, Eric J.,

Karp, Jordan F.,

Pham, Vy T.,

Brown, Patrick J.,

Miller, J. Philip,

Oughli, Hanadi A.,

Roose, Steven P.,

Gebara, Marie A.,

Lenard, Emily,

Flint, Alastair J.,

Yang, Lei,

Mulsant, Benoit H.,

Lavretsky, Helen,

Nicol, Ginger E.,

Reynolds, Charles F.,

Cristancho, Pilar,

Blumberger, Daniel M.,

Gettinger, Torie R.,

Rollman, Bruce L.

2023

Overview

In a pragmatic trial involving older persons with treatment-resistant depression, augmentation of existing antidepressants with aripiprazole was better than augmentation with bupropion or a switch to bupropion.

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Publisher

Massachusetts Medical Society

Subject

Aged

/ Aging

/ Aging General

/ Antidepressants

/ Antidepressive Agents - adverse effects

/ Antidepressive Agents - therapeutic use

/ Aripiprazole