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Liver cell proliferation and tumor promotion by phenobarbital: relevance for humans?
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Journal Article
Liver cell proliferation and tumor promotion by phenobarbital: relevance for humans?
2014
Overview
The anticolvulsant phenobarbital (PB) and other activators of the constitutive androstane receptor (CAR) act as transient inducers of hepatocyte proliferation and as potent nongenotoxic carcinogens in rodent liver. Epidemiological studies, however, did not provide sufcient evidence for liver tumor induction by PB in humans whilst also not entirely ruling out this possibility.
Publisher
Springer Berlin Heidelberg,Springer Nature B.V
Subject
/ Biomedical and Life Sciences
/ Cell Proliferation - drug effects
/ Humans
/ Liver Neoplasms - chemically induced
/ Liver Neoplasms - metabolism
/ Neurons
/ Occupational Medicine/Industrial Medicine
/ Receptors, Cytoplasmic and Nuclear - genetics
/ Receptors, Cytoplasmic and Nuclear - metabolism
/ Tumors
