Asset Details
Do you wish to reserve the book?
Vanin 1: Its Physiological Function and Role in Diseases
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Vanin 1: Its Physiological Function and Role in Diseases
Do you wish to request the book?
Vanin 1: Its Physiological Function and Role in Diseases
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Vanin 1: Its Physiological Function and Role in Diseases
2019
Overview
The enzyme vascular non-inflammatory molecule-1 (vanin 1) is highly expressed at gene and protein level in many organs, such as the liver, intestine, and kidney. Its major function is related to its pantetheinase activity; vanin 1 breaks down pantetheine in cysteamine and pantothenic acid, a precursor of coenzyme A. Indeed, its physiological role seems strictly related to coenzyme A metabolism, lipid metabolism, and energy production. In recent years, many studies have elucidated the role of vanin 1 under physiological conditions in relation to oxidative stress and inflammation. Vanin’s enzymatic activity was found to be of key importance in certain diseases, either for its protective effect or as a sensitizer, depending on the diseased organ. In this review, we discuss the role of vanin 1 in the liver, kidney, intestine, and lung under physiological as well as pathophysiological conditions. Thus, we provide a more complete understanding and overview of its complex function and contribution to some specific pathologies.
Publisher
MDPI AG,MDPI
Subject
/ Amidohydrolases - metabolism
/ Animals
/ Enzymes
/ GPI-Linked Proteins - analysis
/ GPI-Linked Proteins - metabolism
/ Humans
/ Inflammation - physiopathology
/ Intestinal Diseases - metabolism
/ Intestinal Diseases - physiopathology
/ Intestines - physiopathology
/ Kidney Diseases - metabolism
/ Kidney Diseases - physiopathology
/ Liver
/ Liver Diseases - physiopathology
/ Proteins
/ Review
