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Characterization and in vivo evaluation of a bio-corrodible nitrided iron stent
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Characterization and in vivo evaluation of a bio-corrodible nitrided iron stent
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Characterization and in vivo evaluation of a bio-corrodible nitrided iron stent
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Journal Article
Characterization and in vivo evaluation of a bio-corrodible nitrided iron stent
2013
Overview
A bio-corrodible nitrided iron stent was developed using a vacuum plasma nitriding technique. In the nitrided iron stents, the tensile strength, radial strength, stiffness and in vitro electrochemical corrosion rate were significantly increased compared with those of the control pure iron stent. To evaluate its performance in vivo, the deployment of the nitrided iron stents in juvenile pig iliac arteries was performed. At 3 or 6 months postoperatively, the stented vessels remained patent well; however, slight luminal loss resulting from intimal hyperplasia and relative stenosis of the stented vessel segment with piglets growth were observed by 12 months; no thrombosis or local tissue necrosis was found. At 1 month postoperatively, a nearly intact layer of endothelial cells formed on the stented vessel wall. Additionally, a decreased inflammation scoring, considerably corroded struts and corrosion products accumulation were seen. These findings indicate the potential of this nitrided iron stent as an attractive biodegradable stent.
Publisher
Springer US,Springer,Springer Nature B.V
Subject
/ Animals
/ Biological and medical sciences
/ Biomedical Engineering and Bioengineering
/ Ceramics
/ Chemistry and Materials Science
/ Endothelium, Vascular - growth & development
/ Glass
/ Hogs
/ Iron
/ Microscopy, Electron, Scanning
/ Regenerative Medicine/Tissue Engineering
/ Stents
/ Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases
/ Swine
