Asset Details
Do you wish to reserve the book?
Orosensory Detection of Dietary Fatty Acids Is Altered in CB1R−/− Mice
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Orosensory Detection of Dietary Fatty Acids Is Altered in CB1R−/− Mice
Do you wish to request the book?
Orosensory Detection of Dietary Fatty Acids Is Altered in CB1R−/− Mice
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Orosensory Detection of Dietary Fatty Acids Is Altered in CB1R−/− Mice
2018
Overview
Obesity is one of the major public health issues, and its prevalence is steadily increasing all the world over. The endocannabinoid system (ECS) has been shown to be involved in the intake of palatable food via activation of cannabinoid 1 receptor (CB1R). However, the involvement of lingual CB1R in the orosensory perception of dietary fatty acids has never been investigated. In the present study, behavioral tests on CB1R−/− and wild type (WT) mice showed that the invalidation of Cb1r gene was associated with low preference for solutions containing rapeseed oil or a long-chain fatty acid (LCFA), such as linoleic acid (LA). Administration of rimonabant, a CB1R inverse agonist, in mice also brought about a low preference for dietary fat. No difference in CD36 and GPR120 protein expressions were observed in taste bud cells (TBC) from WT and CB1R−/− mice. However, LCFA induced a higher increase in [Ca2+]i in TBC from WT mice than that in TBC from CB1R−/− mice. TBC from CB1R−/− mice also exhibited decreased Proglucagon and Glp-1r mRNA and a low GLP-1 basal level. We report that CB1R is involved in fat taste perception via calcium signaling and GLP-1 secretion.
Publisher
MDPI
Subject
/ Calcium Signaling - genetics
/ Cannabinoid Receptor Antagonists - pharmacology
/ Glucagon-Like Peptide 1 - metabolism
/ Glucagon-Like Peptide-1 Receptor - genetics
/ Glucagon-Like Peptide-1 Receptor - metabolism
/ Male
/ Receptor, Cannabinoid, CB1 - genetics
/ Receptor, Cannabinoid, CB1 - metabolism
/ Receptors, G-Protein-Coupled - genetics
