Asset Details
Do you wish to reserve the book?
Plasma Membrane-Associated Restriction Factors and Their Counteraction by HIV-1 Accessory Proteins
Hey, we have placed the reservation for you!
By the way, why not check out events that you can attend while you pick your title.
Oops! Something went wrong.
Looks like we were not able to place the reservation. Kindly try again later.
Are you sure you want to remove the book from the shelf?
Plasma Membrane-Associated Restriction Factors and Their Counteraction by HIV-1 Accessory Proteins
Do you wish to request the book?
Plasma Membrane-Associated Restriction Factors and Their Counteraction by HIV-1 Accessory Proteins
Please be aware that the book you have requested cannot be checked out. If you would like to checkout this book, you can reserve another copy
We have requested the book for you!
Your request is successful and it will be processed during the Library working hours. Please check the status of your request in My Requests.
Oops! Something went wrong.
Looks like we were not able to place your request. Kindly try again later.
Journal Article
Plasma Membrane-Associated Restriction Factors and Their Counteraction by HIV-1 Accessory Proteins
2019
Overview
The plasma membrane is a site of conflict between host defenses and many viruses. One aspect of this conflict is the host’s attempt to eliminate infected cells using innate and adaptive cell-mediated immune mechanisms that recognize features of the plasma membrane characteristic of viral infection. Another is the expression of plasma membrane-associated proteins, so-called restriction factors, which inhibit enveloped virions directly. HIV-1 encodes two countermeasures to these host defenses: The membrane-associated accessory proteins Vpu and Nef. In addition to inhibiting cell-mediated immune-surveillance, Vpu and Nef counteract membrane-associated restriction factors. These include BST-2, which traps newly formed virions at the plasma membrane unless counteracted by Vpu, and SERINC5, which decreases the infectivity of virions unless counteracted by Nef. Here we review key features of these two antiviral proteins, and we review Vpu and Nef, which deplete them from the plasma membrane by co-opting specific cellular proteins and pathways of membrane trafficking and protein-degradation. We also discuss other plasma membrane proteins modulated by HIV-1, particularly CD4, which, if not opposed in infected cells by Vpu and Nef, inhibits viral infectivity and increases the sensitivity of the viral envelope glycoprotein to host immunity.
Publisher
MDPI AG,MDPI
Subject
/ Antigens
/ BST-2
/ CD4
/ GPI-Linked Proteins - metabolism
/ HIV
/ HIV-1
/ Human immunodeficiency virus
/ Humans
/ Lipids
/ Membrane Glycoproteins - metabolism
/ Membrane Proteins - metabolism
/ Nef
/ Plasma
/ Proteins
/ Review
/ SERINC5
/ Viral Regulatory and Accessory Proteins - metabolism
/ Virions
/ Viruses
/ Vpu
