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Downregulation of autophagy by Met30-mediated Atg9 ubiquitination
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Downregulation of autophagy by Met30-mediated Atg9 ubiquitination
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Journal Article
Downregulation of autophagy by Met30-mediated Atg9 ubiquitination
2021
Overview
Macroautophagy/autophagy is a highly conserved eukaryotic molecular process that facilitates the recycling of superfluous cytoplasmic materials, damaged organelles, and invading pathogens, resulting in proper cellular homeostasis and survival during stress conditions. Autophagy is stringently regulated at multiple stages, including control at transcriptional, translational, and posttranslational levels. In this work, we identified a mechanism by which regulation of autophagy is achieved through the posttranslational modification of Atg9. Here, we show that, in order to limit autophagy to a low, basal level during normal conditions, Atg9 is ubiquitinated and subsequently targeted for degradation in a proteasome-dependent manner through the action of the E3 ligase Met30. When cells require increased autophagy flux to respond to nutrient deprivation, the proteolysis of Atg9 is significantly reduced. Overall, this work reveals an additional layer of mechanistic regulation that allows cells to further maintain appropriate levels of autophagy and to rapidly induce this process in response to stress.
Publisher
National Academy of Sciences
Subject
/ Autophagy-Related Proteins - metabolism
/ Autophagy-Related Proteins - physiology
/ Membrane Proteins - metabolism
/ Membrane Proteins - physiology
/ Proteasome Endopeptidase Complex - metabolism
/ Protein Processing, Post-Translational
/ Saccharomyces cerevisiae - metabolism
/ Saccharomyces cerevisiae Proteins - metabolism
/ Saccharomyces cerevisiae Proteins - physiology
/ Ubiquitin-Protein Ligase Complexes - metabolism
/ Ubiquitin-Protein Ligase Complexes - physiology
