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Graft remodeling during growth following anterior cruciate ligament reconstruction in skeletally immature sheep
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Graft remodeling during growth following anterior cruciate ligament reconstruction in skeletally immature sheep
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Graft remodeling during growth following anterior cruciate ligament reconstruction in skeletally immature sheep
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Journal Article
Graft remodeling during growth following anterior cruciate ligament reconstruction in skeletally immature sheep
2009
Overview
IntroductionRuptures of the anterior cruciate ligament are being diagnosed with increasing frequency in skeletally immature individuals. It was our aim to investigate the graft remodelling process following an autologous, transphyseal reconstruction of the anterior cruciate ligament (ACL) in skeletally immature sheep. We hypothesized that the ligamentisation process in immature sheep is quicker and more complete when compared to adult sheep.Materials and methodsSkeletally immature sheep with an age of 4 months underwent a fully transphyseal ACL reconstruction using an autologous tendon. The animals were subsequently sacrificed at 3, 6, 12 and 24 weeks following surgery. Each group was characterised histomorphometrically, by immunostaining (VEGF, SMA), by transmission electron microscopy (TEM) and biomechanically (UFS Roboter).ResultsThe histomorphometric analysis and presence of VEGF and SMA positive cells demonstrated a rapid return to a ligament like structure. The biomechanical analysis revealed an anteroposterior translation that was still increased even 6 months following surgery.ConclusionAs in adult sheep models, the remodeling of a soft tissue graft used for ACL reconstruction results in a biomechanically inferior substitute. However, the immature tissue seems to remodel faster and more complete when compared to adults.
