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TMEM16A controls EGF-induced calcium signaling implicated in pancreatic cancer prognosis
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TMEM16A controls EGF-induced calcium signaling implicated in pancreatic cancer prognosis
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Journal Article
TMEM16A controls EGF-induced calcium signaling implicated in pancreatic cancer prognosis
2019
Overview
Pancreatic cancer typically spreads rapidly and has poor survival rates. Here, we report that the calcium-activated chloride channel TMEM16A is a biomarker for pancreatic cancer with a poor prognosis. TMEM16A is up-regulated in 75% of cases of pancreatic cancer and high levels of TMEM16A expression are correlated with low patient survival probability. TMEM16A up-regulation is associated with the ligand-dependent EGFR signaling pathway. In vitro, TMEM16A is required for EGF-induced store-operated calcium entry essential for pancreatic cancer cell migration. TMEM16A also has a profound impact on phosphoproteome remodeling upon EGF stimulation. Moreover, molecular actors identified in this TMEM16A-dependent EGFR-induced calcium signaling pathway form a gene set that makes it possible not only to distinguish neuro-endocrine tumors from other forms of pancreatic cancer, but also to subdivide the latter into three clusters with distinct genetic profiles that could reflect their molecular underpinning.
Publisher
National Academy of Sciences
Subject
/ Biomarkers, Tumor - metabolism
/ Calcium
/ Cancer
/ Carcinoma, Pancreatic Ductal - diagnosis
/ Carcinoma, Pancreatic Ductal - mortality
/ Carcinoma, Pancreatic Ductal - pathology
/ Chloride channels (calcium-gated)
/ Epidermal Growth Factor - metabolism
/ Epidermal growth factor receptors
/ Humans
/ Neoplasm Proteins - genetics
/ Neoplasm Proteins - metabolism
/ Pancreatic Neoplasms - diagnosis
/ Pancreatic Neoplasms - mortality
/ Pancreatic Neoplasms - pathology
/ RNA, Small Interfering - metabolism
/ RNA-Seq
/ Survival
/ Tumors
