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ERF115 Controls Root Quiescent Center Cell Division and Stem Cell Replenishment

by Van Leene, Jelle , Vandepoele, Klaas , Van Der Straeten, Dominique , Cools, Toon , Vanderauwera, Sandy , Vandenbussche, Filip , De Veylder, Lieven , De Jaeger, Geert , Heyman, Jefri , Heyndrickx, Ken S. , Vercauteren, Ilse

in Activation / Anaphase-Promoting Complex-Cyclosome - metabolism / Arabidopsis - cytology / Arabidopsis - growth & development / Arabidopsis Proteins - genetics / Arabidopsis Proteins - metabolism / Brasses / Brassinosteroids / Cell cycle / Cell Cycle - genetics / Cell Cycle - physiology / Cell Cycle Proteins - metabolism / Cell division / Cell Division - genetics / Cell Division - physiology / Cell growth / Differentiation / Genes / Individualized Instruction / Limiting factors / Maintenance / Mitosis - genetics / Mitosis - physiology / Peptide Hormones - genetics / Peptide Hormones - metabolism / phytosulfokines / Plant cells / Plant Roots - cytology / Plant Roots - growth & development / Plants / Proteins / Proteolysis / Replenishment / Root development / root meristems / Root tips / Roots / Signal Transduction / Stem Cell Niche / Stem cells / Stem Cells - physiology / transcription (genetics) / transcription factors / Transcription Factors - genetics / Transcription Factors - metabolism / transcriptional activation / ubiquitin-protein ligase

2013

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ERF115 Controls Root Quiescent Center Cell Division and Stem Cell Replenishment

2013

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ERF115 Controls Root Quiescent Center Cell Division and Stem Cell Replenishment

2013

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Journal Article

ERF115 Controls Root Quiescent Center Cell Division and Stem Cell Replenishment

Van Leene, Jelle,

Vandepoele, Klaas,

Van Der Straeten, Dominique,

Cools, Toon,

Vanderauwera, Sandy,

Vandenbussche, Filip,

De Veylder, Lieven,

De Jaeger, Geert,

Heyman, Jefri,

Heyndrickx, Ken S.,

Vercauteren, Ilse

2013

Overview

The quiescent center (QC) plays an essential role during root development by creating a microenvironment that preserves the stem cell fate of its surrounding cells. Despite being surrounded by highly mitotic active cells, QC cells self-renew at a low proliferation rate. Here, we identified the ERF115 transcription factor as a rate-limiting factor of QC cell division, acting as a transcriptional activator of the phytosulfokine PSK5 peptide hormone. ERF115 marks QC cell division but is restrained through proteolysis by the APC/C CCS52A2 ubiquitin ligase, whereas QC proliferation is driven by brassinosteroid-dependent ERF115 expression. Together, these two antagonistic mechanisms delimit ERF115 activity, which is called upon when surrounding stem cells are damaged, revealing a cell cycle regulatory mechanism accounting for stem cell niche longevity.

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Publisher

American Association for the Advancement of Science,The American Association for the Advancement of Science

Subject

Activation

/ Anaphase-Promoting Complex-Cyclosome - metabolism

/ Arabidopsis - cytology

/ Arabidopsis - growth & development

/ Arabidopsis Proteins - genetics

/ Arabidopsis Proteins - metabolism

/ Brasses