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Opposing intrinsic temporal gradients guide neural stem cell production of varied neuronal fates
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Opposing intrinsic temporal gradients guide neural stem cell production of varied neuronal fates
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Journal Article
Opposing intrinsic temporal gradients guide neural stem cell production of varied neuronal fates
2015
Overview
Neural stem cells show age-dependent developmental potentials, as evidenced by their production of distinct neuron types at different developmental times. Drosophila neuroblasts produce long, stereotyped lineages of neurons. We searched for factors that could regulate neural temporal fate by RNA-sequencing lineage-specific neuroblasts at various developmental times. We found that two RNA-binding proteins, IGF-II mRNA-binding protein (Imp) and Syncrip (Syp), display opposing high-to-low and low-to-high temporal gradients with lineage-specific temporal dynamics. Imp and Syp promote early and late fates, respectively, in both a slowly progressing and a rapidly changing lineage. Imp and Syp control neuronal fates in the mushroom body lineages by regulating the temporal transcription factor Chinmo translation. Together, the opposing Imp/Syp gradients encode stem cell age, specifying multiple cell fates within a lineage.
Publisher
American Association for the Advancement of Science,The American Association for the Advancement of Science
Subject
/ Antennas
/ Drosophila melanogaster - genetics
/ Drosophila melanogaster - growth & development
/ Drosophila Proteins - genetics
/ Drosophila Proteins - metabolism
/ Drosophila Proteins - physiology
/ IMP
/ Insects
/ Lobes
/ Mushroom Bodies - growth & development
/ Nerve Tissue Proteins - metabolism
/ Neural Stem Cells - cytology
/ Neurons
/ Proteins
/ RNA-Binding Proteins - genetics
