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The remarkable legacy of a father’s diet on the health of his offspring
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Journal Article
The remarkable legacy of a father’s diet on the health of his offspring
2018
Overview
Fleming examines the remarkable legacy of a father's diet on the health of his offspring. He notes the recognition of the Barker hypothesis, more known as the Developmental Origins of Health and Disease (DOHaD), that maternal factors such as poor diet and physiological condition could adversely influence pregnancy and contribute to offspring risk of cardiometabolic disease in adulthood. Fleming comments on a study by Watkins et al on paternal programming of offspring disease in a mouse model of low-protein diet (LPD) undernutrition and show, through an elegant experimental design, that paternal sperm and seminal plasma each exert specific yet coordinated pathways by which fathers influence the well-being of their progeny.
