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Radical polymerization inside living cells
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Journal Article
Radical polymerization inside living cells
2019
Overview
Polymerization reactions conducted inside cells must be compatible with the complex intracellular environment, which contains numerous molecules and functional groups that could potentially prevent or quench polymerization reactions. Here we report a strategy for directly synthesizing unnatural polymers in cells through free radical photopolymerization using a number of biocompatible acrylic and methacrylic monomers. This offers a platform to manipulate, track and control cellular behaviour by the in cellulo generation of macromolecules that have the ability to alter cellular motility, label cells by the generation of fluorescent polymers for long-term tracking studies, as well as generate a variety of nanostructures within cells. It is remarkable that free radical polymerization chemistry can take place within such complex cellular environments. This demonstration opens up a multitude of new possibilities for how chemists can modulate cellular function and behaviour and for understanding cellular behaviour in response to the generation of free radicals.
A strategy for directly synthesizing unnatural polymers in cells through radical polymerization has now been developed. This approach provides a platform to manipulate, track and control cellular behaviour by the in cellulo generation of macromolecules and a variety of nanostructures.
Publisher
Nature Publishing Group UK,Nature Publishing Group
Subject
/ Acrylates - radiation effects
/ Actin Cytoskeleton - drug effects
/ Aniline Compounds - chemistry
/ Aniline Compounds - radiation effects
/ Aniline Compounds - toxicity
/ Cell Movement - drug effects
/ Chemistry and Materials Science
/ Chemists
/ Humans
/ Methacrylates - radiation effects
/ Monomers
/ Polymerization - radiation effects
/ Polymers
/ Polymethacrylic Acids - chemical synthesis
/ Polystyrenes - chemical synthesis
/ Propane - analogs & derivatives
/ Styrenes - radiation effects
/ Tracking
