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The Use of Hematopoietic Stem Cells for Heart Failure: A Systematic Review

by Shirvani, Daniel , Nelson, Pierce , Laksman, Zachary , Seth, Jayant , Vaibhav, Venkat , Sharma, Sohat , Leong, Cameron J. , Shokravi, Arveen , Luo, Yuchen

in Angiogenesis / Beta blockers / Blood pressure / Bone marrow / Cardiac function / Cardiac patients / Cardiomyocytes / Cardiomyopathy / Cardiovascular disease / Children / Database searching / Ejection fraction / Health aspects / Heart attack / Heart attacks / Heart failure / Heart Failure - pathology / Heart Failure - therapy / Hematopoietic Stem Cell Transplantation - methods / Hematopoietic stem cells / Hematopoietic Stem Cells - cytology / Hematopoietic Stem Cells - metabolism / Hospitalization / Humans / Internet/Web search services / Ischemia / Medical research / Medicine, Experimental / Mortality / Online searching / Review / Stem cell transplantation / Stem cells / Transplantation / Treatment Outcome / Type 2 diabetes

2024

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The Use of Hematopoietic Stem Cells for Heart Failure: A Systematic Review

by Shirvani, Daniel , Nelson, Pierce , Laksman, Zachary , Seth, Jayant , Vaibhav, Venkat , Sharma, Sohat , Leong, Cameron J. , Shokravi, Arveen , Luo, Yuchen

2024

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The Use of Hematopoietic Stem Cells for Heart Failure: A Systematic Review

by Shirvani, Daniel , Nelson, Pierce , Laksman, Zachary , Seth, Jayant , Vaibhav, Venkat , Sharma, Sohat , Leong, Cameron J. , Shokravi, Arveen , Luo, Yuchen

2024

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Journal Article

The Use of Hematopoietic Stem Cells for Heart Failure: A Systematic Review

Shirvani, Daniel,

Nelson, Pierce,

Laksman, Zachary,

Seth, Jayant,

Vaibhav, Venkat,

Sharma, Sohat,

Leong, Cameron J.,

Shokravi, Arveen,

Luo, Yuchen

2024

Overview

The purpose of this review is to summarize the current understanding of the therapeutic effect of stem cell-based therapies, including hematopoietic stem cells, for the treatment of ischemic heart damage. Following PRISMA guidelines, we conducted electronic searches in MEDLINE, and EMBASE. We screened 592 studies, and included RCTs, observational studies, and cohort studies that examined the effect of hematopoietic stem cell therapy in adult patients with heart failure. Studies that involved pediatric patients, mesenchymal stem cell therapy, and non-heart failure (HF) studies were excluded from our review. Out of the 592 studies, 7 studies met our inclusion criteria. Overall, administration of hematopoietic stem cells (via intracoronary or myocardial infarct) led to positive cardiac outcomes such as improvements in pathological left-ventricular remodeling, perfusion following acute myocardial infarction, and NYHA symptom class. Additionally, combined death, rehospitalization for heart failure, and infarction were significantly lower in patients treated with bone marrow-derived hematopoietic stem cells. Our review demonstrates that hematopoietic stem cell administration can lead to positive cardiac outcomes for HF patients. Future studies should aim to increase female representation and non-ischemic HF patients.

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