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18FNaF PET/CT as a Marker for Fibrodysplasia Ossificans Progressiva: From Molecular Mechanisms to Clinical Applications in Bone Disorders

by Verheij, Vincent A. , Raijmakers, Pieter G. H. M. , Botman, Esmée , Teunissen, Bernd P. , Bökenkamp, Arend , Rosenberg, Neeltje M. , Schwarte, Lothar A. , Garrelfs, Mark R. , Yaqub, Maqsood , de Ruiter, Ruben D. , Lammertsma, Adriaan A. , Eekhoff, Elisabeth M. W. , Boellaard, Ronald , Zwama, Jolien , Micha, Dimitra

in 18F-sodium fluoride (18F-NaF) / Animals / Biomarkers - metabolism / Bisphosphonates / Bone diseases / Bone growth / Bone imaging / Bone turnover / Cartilage / Computed tomography / Connective tissue diseases / fibrodysplasia ossificans progressiva / Fluorides / Fluorine Radioisotopes / heterotopic ossification / Humans / Hydroxyapatite / Inflammation / Localization / Medical imaging / Metabolism / Mineralization / Molecular modelling / musculoskeletal development / Myositis ossificans / Myositis Ossificans - diagnostic imaging / Myositis Ossificans - genetics / Myositis Ossificans - metabolism / Ossification (ectopic) / osteoblasts / Osteogenesis / Pharmacokinetics / Positron emission tomography / Positron Emission Tomography Computed Tomography - methods / positron emission tomography/computed tomography (PET/CT) / Review / Rheumatoid arthritis / Scintigraphy / Sodium Fluoride / Stem cells / Tomography

2024

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18FNaF PET/CT as a Marker for Fibrodysplasia Ossificans Progressiva: From Molecular Mechanisms to Clinical Applications in Bone Disorders

2024

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18FNaF PET/CT as a Marker for Fibrodysplasia Ossificans Progressiva: From Molecular Mechanisms to Clinical Applications in Bone Disorders

2024

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Journal Article

18FNaF PET/CT as a Marker for Fibrodysplasia Ossificans Progressiva: From Molecular Mechanisms to Clinical Applications in Bone Disorders

Verheij, Vincent A.,

Raijmakers, Pieter G. H. M.,

Botman, Esmée,

Teunissen, Bernd P.,

Bökenkamp, Arend,

Rosenberg, Neeltje M.,

Schwarte, Lothar A.,

Garrelfs, Mark R.,

Yaqub, Maqsood,

de Ruiter, Ruben D.,

Lammertsma, Adriaan A.,

Eekhoff, Elisabeth M. W.,

Boellaard, Ronald,

Zwama, Jolien,

Micha, Dimitra

2024

Overview

Fibrodysplasia ossificans progressiva (FOP) is a rare genetic bone disorder characterized by episodic flare-ups in connective tissue, which are frequently followed by the formation of heterotopic ossification. The absence of available plasma-soluble biomarkers for flare-ups or heterotopic bone formation poses severe challenges to the monitoring of disease activity to measure or predict disease progression. Recently, 18-fluor-sodium fluoride positron emission tomography/computed tomography ([18F]NaF PET/CT) was introduced as a potential marker for ossifying FOP activity. This review discusses the pharmacokinetics of [18F]NaF in relation to the pathophysiology of FOP, and its use as a marker of local bone metabolism in a variety of bone-related disorders. In addition, the review specifically addresses the applicability of [18F]NaF PET/CT imaging in FOP as a monitoring modality.

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Publisher

MDPI AG,MDPI

Subject

18F-sodium fluoride (18F-NaF)

/ Animals

/ Biomarkers - metabolism