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Glycogen synthase kinase 3: A key regulator of cellular fate
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Journal Article
Glycogen synthase kinase 3: A key regulator of cellular fate
2007
Overview
The serine/threonine kinase glycogen synthase kinase-3 (GSK-3) was initially identified as a key regulator of insulin-dependent glycogen synthesis. GSK-3 was subsequently shown to function in a wide range of cellular processes including differentiation, growth, motility and apoptosis. Aberrant regulation of GSK-3 has been implicated in a range of human pathologies including Alzheimer's disease, non-insulin-dependent diabetes mellitus (NIDDM) and cancer. As a consequence, the regulation of GSK-3 and the therapeutic potential of GSK-3 inhibitors have become key areas of investigation. This review will focus on the mechanisms of GSK-3 regulation, with emphasis on modulation by upstream signals, control of substrate specificity and GSK-3 localisation. The details of these mechanisms will be discussed in the context of specific signalling pathways.
Publisher
Basel : Birkhäuser-Verlag,Springer Nature B.V,Birkhäuser-Verlag
Subject
/ Animals
/ Diabetes mellitus (insulin dependent)
/ Diabetes mellitus (non-insulin dependent)
/ genetics
/ Glycogen
/ Glycogen Synthase Kinase 3 - antagonists & inhibitors
/ Glycogen Synthase Kinase 3 - chemistry
/ Glycogen Synthase Kinase 3 - genetics
/ Glycogen Synthase Kinase 3 - physiology
/ Glycogen synthase kinase-3 (GSK-3)
/ Hedgehog Proteins - metabolism
/ Humans
/ Insulin
/ kinase
/ Kinases
/ Mitosis
/ noninsulin-dependent diabetes mellitus
/ Protein-serine/threonine kinase
/ Review
/ Sequence Homology, Amino Acid
/ serine
